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GYKI 52466 dihydrochloride
Catalog No. T11522Cas No. 2319722-40-0
Alias GYKI-52466 dihydrochloride, GYKI52466 dihydrochloride, GYKI 52466 2HCl
GYKI 52466 dihydrochloride (GYKI 52466 2HCl) is a highly potent, orally active and selective AMPA/Kainate receptor antagonist with good blood-brain permeability and anticonvulsant activity that can be used to study neurological diseases such as Parkinson's and epilepsy.
GYKI 52466 dihydrochloride
Catalog No. T11522Alias GYKI-52466 dihydrochloride, GYKI52466 dihydrochloride, GYKI 52466 2HClCas No. 2319722-40-0
GYKI 52466 dihydrochloride (GYKI 52466 2HCl) is a highly potent, orally active and selective AMPA/Kainate receptor antagonist with good blood-brain permeability and anticonvulsant activity that can be used to study neurological diseases such as Parkinson's and epilepsy.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $113 | In Stock |
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Purity:99.38%
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Product Introduction
Bioactivity
Chemical Properties
| Description | GYKI 52466 dihydrochloride (GYKI 52466 2HCl) is a highly potent, orally active and selective AMPA/Kainate receptor antagonist with good blood-brain permeability and anticonvulsant activity that can be used to study neurological diseases such as Parkinson's and epilepsy. |
| Targets&IC50 | AMPA receptor:11 μM , Kainate receptor:7.5 μM |
| In vitro | In cultured rat hippocampal neurons, GYKI 52466 dihydrochloride (0.3-100 μM) was able to inhibit inward currents activated by AMPA and Kainate receptors. [1] |
| In vivo | GYKI 52466 dihydrochloride (1.76-13.2 mg/kg; single administration), given by intraperitoneal injection to DBA/2 mice, was able to provide effective anticonvulsant protection against sound-induced seizures. [2] |
| Alias | GYKI-52466 dihydrochloride, GYKI52466 dihydrochloride, GYKI 52466 2HCl |
| Molecular Weight | 366.24 |
| Formula | C17H17Cl2N3O2 |
| Cas No. | 2319722-40-0 |
Storage & Solubility Information
| Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
| Solubility Information | DMSO: 1 mg/mL(2.73 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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