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Ceramides Mixture

Catalog No. T10760Cas No. 100403-19-8

Ceramides Mixture, an endogenous ceramide, consists of hydroxy and non-hydroxy fatty acid-containing ceramides. It is involved in the regulation of cell cycle arrest, growth inhibition, and modulation of telomerase activity.

Ceramides Mixture

Ceramides Mixture

Catalog No. T10760Cas No. 100403-19-8
Ceramides Mixture, an endogenous ceramide, consists of hydroxy and non-hydroxy fatty acid-containing ceramides. It is involved in the regulation of cell cycle arrest, growth inhibition, and modulation of telomerase activity.
Pack SizePriceAvailabilityQuantity
1 mg$32In Stock
2 mg$45In Stock
5 mg$74In Stock
10 mg$108In Stock
25 mg$178In Stock
50 mg$272In Stock
100 mg$397In Stock
500 mg$936In Stock
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Product Introduction

Bioactivity
Description
Ceramides Mixture, an endogenous ceramide, consists of hydroxy and non-hydroxy fatty acid-containing ceramides. It is involved in the regulation of cell cycle arrest, growth inhibition, and modulation of telomerase activity.
In vitro
Endogenous Ceramides inhibits mRNA synthesis of telomerase reverse transcriptase and telomerase activity via inactivation of the c-Myc transcription factor in the A549 human lung adenocarcinoma cell line. The sustained generation of long-chain endogenous ceramide requires the biochemical recycling of the sphingosine backbone of C6-ceramide, which involves deacylation and reacylation of ceramide for the generation of endogenous long-chain ceramide, most likely by CoA-dependent ceramide synthase, which is inhibited by fumonisin B1. In A549 cells the generation of long-chain endogenous ceramide mediates the effects of exogenous C6-ceramide on growth inhibition, cell cycle arrest, and the modulation of telomerase activity [1].
Chemical Properties
Cas No.100403-19-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Methanol: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 1 mg/ml, Sonication and heating for 30 minutes are recommended.
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: < 1 mg/mL (insoluble or slightly soluble)
Chloroform: 7.69 mg/ml

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