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Adefovir

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Purity:100%

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COA LCMS HNMR

Adefovir

Catalog No. T7447Cas No. 106941-25-7

Adefovir is an acyclic nucleoside phosphonate that acts as a reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.

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Pack Size	Price	Availability
25 mg	$41	In Stock
50 mg	$66	In Stock
100 mg	$97	In Stock
200 mg	$145	In Stock

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Product Introduction

Bioactivity

Description	Adefovir is an acyclic nucleoside phosphonate that acts as a reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.
In vitro	adefovir is a potent inhibitor of DHBV replication that inhibits CCC DNA amplification but does not effectively prevent the formation of CCC DNA from incoming viral genomes[1].
Cell Research	The effect of adefovir on viral CCC DNA synthesis was examined with primary cultures of DHBV-infected fetal hepatocytes.?Adefovir was administered for six consecutive days starting one day before or four days after DHBV inoculation.?Dose-dependent inhibition of both virion release in culture supernatants and synthesis of intracellular viral DNA was observed[1].

Chemical Properties

Molecular Weight	273.19
Formula	C8H12N5O4P
Cas No.	106941-25-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 2.5 mM

DMSO: Insoluble

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
5 mM	0.7321 mL	3.6605 mL	7.3209 mL	36.6046 mL
10 mM	0.3660 mL	1.8302 mL	3.6605 mL	18.3023 mL
20 mM	0.1830 mL	0.9151 mL	1.8302 mL	9.1511 mL
50 mM	0.0732 mL	0.3660 mL	0.7321 mL	3.6605 mL
100 mM	0.0366 mL	0.1830 mL	0.3660 mL	1.8302 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc