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Tenofovir alafenamide

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Purity:99.97%

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COA HPLC HNMR

Tenofovir alafenamide

Catalog No. T2409Cas No. 379270-37-8

Tenofovir alafenamide (GS-7340) is a nucleotide reverse transcriptase inhibitor (NRTI) and a novel ester prodrug of the antiretroviral tenofovir.

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Pack Size	Price	Availability
5 mg	$45	In Stock
10 mg	$63	In Stock
25 mg	$88	In Stock
50 mg	$126	In Stock
100 mg	$171	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Product Introduction

Bioactivity

Description	Tenofovir alafenamide (GS-7340) is a nucleotide reverse transcriptase inhibitor (NRTI) and a novel ester prodrug of the antiretroviral tenofovir.
In vitro	GS-7340 has a potent anti-HIV activity with IC50 of 0.005 μM. [1] GS 7340 has a half-life of 90 min in human plasma and a half-life of 28.3 min in an MT-2 cell extract at 37°C. [2] the hepatic uptake of GS-7340 isfacilitated by OATP1B1 and OATP1B3, respectively. GS-7340 inhibits HBV reverse transcriptase after being converted to the pharmacologically active form, TFV-DP. [3]
In vivo	In male beagle dogs, GS 7340 (10 mg/kg, p.o.) results in an enhanced distribution to lymphatic tissue. [2]
Alias	GS-7340

Chemical Properties

Molecular Weight	476.47
Formula	C21H29N6O5P
Cas No.	379270-37-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (115.43 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 88 mg/mL (184.7 mM)

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0988 mL	10.4938 mL	20.9877 mL	104.9384 mL
5 mM	0.4198 mL	2.0988 mL	4.1975 mL	20.9877 mL
10 mM	0.2099 mL	1.0494 mL	2.0988 mL	10.4938 mL
20 mM	0.1049 mL	0.5247 mL	1.0494 mL	5.2469 mL
50 mM	0.0420 mL	0.2099 mL	0.4198 mL	2.0988 mL
100 mM	0.0210 mL	0.1049 mL	0.2099 mL	1.0494 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc