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Tenofovir alafenamide
Catalog No. T2409Cas No. 379270-37-8
Alias GS-7340
Tenofovir alafenamide (GS-7340) is a nucleotide reverse transcriptase inhibitor (NRTI) and a novel ester prodrug of the antiretroviral tenofovir.
Tenofovir alafenamide
Catalog No. T2409Alias GS-7340Cas No. 379270-37-8
Tenofovir alafenamide (GS-7340) is a nucleotide reverse transcriptase inhibitor (NRTI) and a novel ester prodrug of the antiretroviral tenofovir.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $45 | In Stock | |
| 10 mg | $63 | In Stock | |
| 25 mg | $88 | In Stock | |
| 50 mg | $126 | In Stock | |
| 100 mg | $171 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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Purity:99.97%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Tenofovir alafenamide (GS-7340) is a nucleotide reverse transcriptase inhibitor (NRTI) and a novel ester prodrug of the antiretroviral tenofovir. |
| In vitro | Tenofovir alafenamide has a potent anti-HIV activity with IC50 of 0.005 μM. [1] GS 7340 has a half-life of 90 min in human plasma and a half-life of 28.3 min in an MT-2 cell extract at 37°C. [2] the hepatic uptake of Tenofovir alafenamide isfacilitated by OATP1B1 and OATP1B3, respectively. Tenofovir alafenamide inhibits HBV reverse transcriptase after being converted to the pharmacologically active form, TFV-DP. [3] |
| In vivo | In male beagle dogs, GS 7340 (10 mg/kg, p.o.) results in an enhanced distribution to lymphatic tissue. [2] |
| Alias | GS-7340 |
| Molecular Weight | 476.47 |
| Formula | C21H29N6O5P |
| Cas No. | 379270-37-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (115.43 mM)  H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 88 mg/mL (184.7 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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