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Tenofovir alafenamide fumarate

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Catalog No. T41249Cas No. 379270-38-9
Alias GS-7340 fumarate

Tenofovir alafenamide fumarate (GS-7340 fumarate) is an orally available precursor of Tenofovir with anti-HIV activity, used to prevent HIV infection.

Tenofovir alafenamide fumarate

Tenofovir alafenamide fumarate

🥰Excellent
Purity: 99.95%
Catalog No. T41249Alias GS-7340 fumarateCas No. 379270-38-9
Tenofovir alafenamide fumarate (GS-7340 fumarate) is an orally available precursor of Tenofovir with anti-HIV activity, used to prevent HIV infection.
Pack SizePriceAvailabilityQuantity
5 mg$43In Stock
10 mg$61In Stock
25 mg$95In Stock
50 mg$125In Stock
100 mg$169In Stock
500 mg$428In Stock
1 mL x 10 mM (in DMSO)$57In Stock
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Purity:99.95%
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Product Introduction

Bioactivity
Description
Tenofovir alafenamide fumarate (GS-7340 fumarate) is an orally available precursor of Tenofovir with anti-HIV activity, used to prevent HIV infection.
In vitro
Tenofovir alafenamide fumarate antiviral activity was similar in all cell types, ranging from 5 to 7 nM, whereas CC50 varied from 4.7 to 42 μM for MT-4 and MT-2 cells. The antiviral activity of TAF was evaluated against a panel of HIV-1 and HIV-2 isolates, including HIV-1 M group subtypes A to G, as well as group N and O isolates. Overall, TAF EC50 ranged from 0.1 to 12 nM, with an average EC50 of 3.5 nM, compared to an average EC50 of 11.8 nM for AZT, used as an internal control, for 29 major HIV-1 isolates tested in PBMC. For HIV-2 isolates, the average EC50 is 1.8 nM for TAF and 6.4 nM for AZT.[2]
In vivo
Tenofovir alafenamide fumarate (GS-7340 fumarate), an amidate prodrug of Tenofovir, exhibits enhanced oral bioavailability and plasma stability compared to Tenofovir disoproxil fumarate (TDF) [1].
AliasGS-7340 fumarate
Chemical Properties
Molecular Weight592.54
FormulaC25H33N6O9P
Cas No.379270-38-9
SmilesOC(=O)\C=C\C(O)=O.CC(C)OC(=O)[C@H](C)N[P@](=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)Oc1ccccc1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 25 mg/mL (42.19 mM), Sonication is recommended.
DMSO: 200 mg/mL (337.53 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.6876 mL8.4382 mL16.8765 mL84.3825 mL
5 mM0.3375 mL1.6876 mL3.3753 mL16.8765 mL
10 mM0.1688 mL0.8438 mL1.6876 mL8.4382 mL
20 mM0.0844 mL0.4219 mL0.8438 mL4.2191 mL
DMSO
1mg5mg10mg50mg
50 mM0.0338 mL0.1688 mL0.3375 mL1.6876 mL
100 mM0.0169 mL0.0844 mL0.1688 mL0.8438 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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2 Enter the in vivo formulation:
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