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2-Methylcitric acid
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Catalog No. T10076Cas No. 6061-96-7
Alias Methylcitric acid
2-Methylcitric acid (Methylcitric acid) is a metabolic marker of methylmalonic acidemia that induces mitochondrial permeability transition (PT) and reduces ATP production in brain mitochondria.
2-Methylcitric acid
🥰Excellent
Catalog No. T10076Alias Methylcitric acidCas No. 6061-96-7
2-Methylcitric acid (Methylcitric acid) is a metabolic marker of methylmalonic acidemia that induces mitochondrial permeability transition (PT) and reduces ATP production in brain mitochondria.
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Product Introduction
Bioactivity
Chemical Properties
| Description | 2-Methylcitric acid (Methylcitric acid) is a metabolic marker of methylmalonic acidemia that induces mitochondrial permeability transition (PT) and reduces ATP production in brain mitochondria. |
| In vitro | 2-Methylcitric acid has a significant effect on glutamate metabolism and interferes with mitochondrial function through a variety of mechanisms. It inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM, which in turn affects glutamate oxidation. In addition, 2-Methylcitric acid acts on mitochondria at concentrations of 1-3 mM, causing a significant decrease in membrane potential and mitochondrial swelling, a process that is caused by its ability to inhibit calcium loading supported by different substrates.2-Methylcitric acid has been shown to interfere with mitochondrial function by inhibiting glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM. The compound disrupts mitochondrial energy homeostasis by inhibiting glutamate dehydrogenase activity and acting as an inducer of permeability transition. Notably, although 2-Methylcitric acid disrupts mitochondrial energy homeostasis, it does not significantly affect glutamate transport function in liver mitochondria. [1] |
| Alias | Methylcitric acid |
| Molecular Weight | 206.15 |
| Formula | C7H10O7 |
| Cas No. | 6061-96-7 |
| Smiles | O=C(O)CC(O)(C(=O)O)C(C(=O)O)C |
| Relative Density. | 1.178g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (388.07 mM), Sonication is recommended. H2O: 80 mg/mL (388.07 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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