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Description | 2-Methylcitric acid trisodium (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. It accumulates in methylmalonic and propionic acidemias. |
In vitro | 2-Methylcitric acid impairs glutamate metabolism and induces permeability transition in brain mitochondria. It inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM. 2-Methylcitric acid (1-3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca2+-loaded mitochondria supported by different substrates. 2-Methylcitric acid behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis. 2-Methylcitric acid does not significantly impair mitochondrial glutamate transport. 2-Methylcitric acid does not significantly impair glutamate mitochondrial transport in liver mitochondria. |
Alias | Methylcitric acid trisodium |
Molecular Weight | 229.14 |
Formula | C7H10NaO7 |
Cas No. | 117041-96-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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