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Doxylamine succinate
🥰Excellent
Catalog No. T1115Cas No. 562-10-7
Alias Decapryn
Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate (Decapryn) competitively blocks the histamine H1 receptor and limits the typical allergic and anaphylactic responses, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contraction of the gastrointestinal smooth muscle, caused by actions of histamine on bronchial and gastrointestinal smooth muscles, and on capillaries. This drug also prevents histamine-induced pain and itching of the skin and mucous membranes.
Doxylamine succinate
🥰Excellent
Purity: 100%
Catalog No. T1115Alias DecaprynCas No. 562-10-7
Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate (Decapryn) competitively blocks the histamine H1 receptor and limits the typical allergic and anaphylactic responses, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contraction of the gastrointestinal smooth muscle, caused by actions of histamine on bronchial and gastrointestinal smooth muscles, and on capillaries. This drug also prevents histamine-induced pain and itching of the skin and mucous membranes.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $37 | In Stock | |
| 50 mg | $50 | In Stock | |
| 100 mg | $61 | In Stock | |
| 200 mg | $102 | In Stock | |
| 500 mg | $167 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate (Decapryn) competitively blocks the histamine H1 receptor and limits the typical allergic and anaphylactic responses, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contraction of the gastrointestinal smooth muscle, caused by actions of histamine on bronchial and gastrointestinal smooth muscles, and on capillaries. This drug also prevents histamine-induced pain and itching of the skin and mucous membranes. |
| In vitro | In B6C3F1 mice, the impact of Doxylamine on microsomal enzyme activity and serum thyroid hormone levels was investigated by administering Doxylamine succinate for 7 or 15 days with dietary incorporation at levels of 0, 40, 375, 750, or 1500 ppm, corresponding to the free base form of Doxylamine. Findings reveal that Doxylamine acts as an inducer of hepatic microsomal cytochrome P450 enzymes, consistent with the hypothesis that Doxylamine increases liver enzyme activities involved in T4 metabolism in B6C3F1 mice. |
| Alias | Decapryn |
| Molecular Weight | 388.46 |
| Formula | C21H28N2O5 |
| Cas No. | 562-10-7 |
| Smiles | OC(=O)CCC(O)=O.CN(C)CCOC(C)(C1=CC=CC=C1)C1=NC=CC=C1 |
| Relative Density. | 1.043g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (257.43 mM) H2O: 100 mg/mL (257.43 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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