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Mirtazapine

Mirtazapine
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Purity:99.3%
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Mirtazapine

Catalog No. T0137Cas No. 85650-52-8
Mirtazapine (6-Azamianserin) is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury.
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Pack SizePriceAvailabilityQuantity
5 mg$34In Stock
10 mg$46In Stock
25 mg$73In Stock
50 mg$98In Stock
100 mg$156In Stock
200 mg$265In Stock
500 mg$473In Stock
1 mL x 10 mM (in DMSO)$86In Stock
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Product Introduction

Bioactivity
Description
Mirtazapine (6-Azamianserin) is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury.
In vitro
Mirtazapine displays marked affinity for cloned, human alpha2A-adrenergic (AR) receptors at which it blocks noradrenaline (NA)-induced stimulation of guanosine-5'-O-(3-[35S]thio)-triphosphate ([35S]-GTPgammaS) binding. Mirtazapine shows high affinity for cloned, human serotonin (5-HT)2C receptors at which it abolishes 5-HT-induced phosphoinositide generation. Mirtazapine markedly elevates dialysate levels of NA and, in FCX, DA, whereas 5-HT is not affected.[1] Mirtazapine enhances the effectiveness of the electrical stimulation of the ascending 5-HT pathway by blocking both alpha-2 adrenergic auto- and heteroreceptors. Mirtazapine blocks the suppressant effect of microiontophoretically applied norepinephrine (NE) on the firing activity of CA3 dorsal hippocampus pyramidal neurons, indicating their antagonistic effects on postsynaptic alpha-2 adrenoceptors. [2]
In vivo
Mirtazapine (10-250 mg/kg i.v.) enhances dose-dependently the firing activity of the 5-HT neurons in naive rats, but not in 6-hydroxydopamine-pretreated rats. [2] Mirtazapine (5 mg/kg/day, s.c., using osmotic minipumps) increases the spontaneous firing activity of locus coeruleus noradrenaline (NA) neurons in male Sprague-Dawley rats. Mirtazapine antagonizes both the enhancing effect of a low dose (10 mg/kg, i.v.) and the reducing effect of a high dose (100 mg/kg, i.v.) of the alpha 2-adrenoceptor agonist clonidine on the effectiveness of the electrical stimulation of the ascending 5-HT pathway in suppressing the firing activity of dorsal hippocampus CA3 pyramidal neurons. [3] Mirtazapine (5 mg/kg s.c.) only slightly affects DOPAC and homovanillic acid levels in the striatum, hardly affects 5-HT release in freely moving rats, but clearly increased 5-hydroxyindole acetic acid. [4]
Alias6-Azamianserin, Org3770
Chemical Properties
Molecular Weight265.35
FormulaC17H19N3
Cas No.85650-52-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
Ethanol: 53 mg/mL (199.73 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 55 mg/mL (207.27 mM)
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM3.7686 mL18.8430 mL37.6861 mL188.4304 mL
5 mM0.7537 mL3.7686 mL7.5372 mL37.6861 mL
10 mM0.3769 mL1.8843 mL3.7686 mL18.8430 mL
20 mM0.1884 mL0.9422 mL1.8843 mL9.4215 mL
50 mM0.0754 mL0.3769 mL0.7537 mL3.7686 mL
100 mM0.0377 mL0.1884 mL0.3769 mL1.8843 mL

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