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SBN-284

SBN-284
SBN-284 (compound 3x) acts as a dual inhibitor of cholinesterases (Cholinesterases) and NLRP3 inflammasomes, demonstrating blood-brain barrier permeability. It exhibits IC50 values of 0.37, 0.31, and 0.29 μM against EeAChE, hAChE, and eqBChE respectively, and an EC50 value of 1 μM against NLRP3. SBN-284 is utilized in Alzheimers disease research.
Catalog No. T88928
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SBN-284

Catalog No. T88928
SBN-284 (compound 3x) acts as a dual inhibitor of cholinesterases (Cholinesterases) and NLRP3 inflammasomes, demonstrating blood-brain barrier permeability. It exhibits IC50 values of 0.37, 0.31, and 0.29 μM against EeAChE, hAChE, and eqBChE respectively, and an EC50 value of 1 μM against NLRP3. SBN-284 is utilized in Alzheimers disease research.
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Product Introduction

Bioactivity
Description
SBN-284 (compound 3x) acts as a dual inhibitor of cholinesterases (Cholinesterases) and NLRP3 inflammasomes, demonstrating blood-brain barrier permeability. It exhibits IC50 values of 0.37, 0.31, and 0.29 μM against EeAChE, hAChE, and eqBChE respectively, and an EC50 value of 1 μM against NLRP3. SBN-284 is utilized in Alzheimers disease research.
Targets&IC50
Ee AChE:0.37 μM, eqBCHE:0.29 μM, hAChE:0.31 μM, NLRP3 inflammasome:1 μM (EC50)
Chemical Properties
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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