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Antimalarial agent 44
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Catalog No. T201453
Antimalarial agent 44 (Compound 3) is an antiparasitic agent effective against malaria. It exhibits good permeability in MDCK-MDR1 cell monolayers and has a high clearance rate in mouse liver microsomes.
Antimalarial agent 44
😃Good
Catalog No. T201453
Antimalarial agent 44 (Compound 3) is an antiparasitic agent effective against malaria. It exhibits good permeability in MDCK-MDR1 cell monolayers and has a high clearance rate in mouse liver microsomes.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Antimalarial agent 44 (Compound 3) is an antiparasitic agent effective against malaria. It exhibits good permeability in MDCK-MDR1 cell monolayers and has a high clearance rate in mouse liver microsomes. |
| In vitro | Antimalarial agent 44 exhibits inhibitory effects against Leishmania infantum, Plasmodium falciparum, Trypanosoma brucei brucei, Trypanosoma brucei rhodesiense, and Trypanosoma cruzi with EC 50 values of 1.8, 3, 15, 9.1, and 20 μM, respectively. At pH 7.4, this compound demonstrates favorable cellular permeability in MDCK-MDR1 cell monolayers, achieving a Papp AB of 3.5 μcm/s. Moreover, Antimalarial agent 44 is efficiently cleared in mouse liver microsomes at pH 7.4, with an intrinsic clearance (CLint) greater than 580 μL/min/mg. |
| Molecular Weight | 663.72 |
| Formula | C37H37N5O7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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