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SB-3CT
🥰Excellent
Catalog No. T2009Cas No. 292605-14-2
SB-3CT is a potent and specific gelatinase inhibitor for MMP-2 (Ki = 13.9 nM) and MMP-9 (Ki = 600 nM).
SB-3CT
🥰Excellent
Purity: 99.38%
Catalog No. T2009Cas No. 292605-14-2
SB-3CT is a potent and specific gelatinase inhibitor for MMP-2 (Ki = 13.9 nM) and MMP-9 (Ki = 600 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $41 | In Stock | |
| 2 mg | $59 | In Stock | |
| 5 mg | $90 | In Stock | |
| 10 mg | $162 | In Stock | |
| 25 mg | $259 | In Stock | |
| 50 mg | $387 | In Stock | |
| 100 mg | $576 | In Stock | |
| 500 mg | $1,260 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $90 | In Stock |
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Purity:99.38%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | SB-3CT is a potent and specific gelatinase inhibitor for MMP-2 (Ki = 13.9 nM) and MMP-9 (Ki = 600 nM). |
| Targets&IC50 | MMP2:13.9 nM(Ki), MMP9:600 nM(Ki) |
| In vitro | In a permanent cerebral ischemia mouse model induced by an embolus, SB-3CT protects neurons from ischemic cell death by inhibiting the degradation of neuronal adhesion proteins. Furthermore, daily intraperitoneal injections of SB-3CT (5-50 mg/kg) in the L-CI.5sT murine lymphoma model significantly hinders liver cancer cell metastasis. Likewise, in a model of osteolytic metastasis of human prostate cancer cells, daily intraperitoneal administration of SB-3CT (50 mg/kg) curtails cell growth, bone resorption, and angiogenesis. |
| In vivo | SB-3CT is capable of reducing osteolytic responses, aiding in the maintenance of bone integrity. In PC3 tumor cells, SB-3CT inhibits cellular growth. Within the basement membrane matrix, SB-3CT directly suppresses the infiltration of bone marrow endothelial cells and tubule formation. |
| Kinase Assay | kinase assays: PI3K inhibition by LY294002 is determined in a radiometric assay using purified, recombinant enzymes with 1?μM ATP. The kinase reaction is carried out for 1?hour at room temperature (24oC) and is terminated by addition of PBS. IC50 values are subsequently determined using a sigmoidal dose–response curve fit (variable slope). CK2 and GSK3β (glycogen synthase kinase 3β) inhibition is established by kinase selectivity screening. LY294002 is tested against the Upstate panel of kinases in 10?μM ATP. |
| Cell Research | SB-3CT is dissolved in DMSO (10 mM) and stored (-22°C), and then diluted with appropriate media (DMSO 1%) before use[2]. PC3 cells are seeded in 35-mm dishes (5×104 cells/dish) in complete culture medium. The next day, the medium is replaced with complete medium supplemented with 1% DMSO alone (vehicle) or SB-3CT (final concentrations 0.1-50 μM) in 1% DMSO. At various times, the cells are harvested with trypsin and counted[2]. |
| Molecular Weight | 306.4 |
| Formula | C15H14O3S2 |
| Cas No. | 292605-14-2 |
| Smiles | O=S(=O)(CC1CS1)c1ccc(Oc2ccccc2)cc1 |
| Relative Density. | 1.329 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 6.1 mg/mL (20 mM) DMSO: 55 mg/mL (179.5 mM)  | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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