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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 μg | $330 | 35 days | |
50 μg | $623 | 35 days | |
100 μg | $1,170 | 35 days |
Description | Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTE4 is a metabolite of 14,15-LTC4 and 14,15-LTD4, an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. These metabolites are classified as eoxins because they are formed mostly by eosinophils. Mast cells and nasal polyps can synthesize 14,15-LTC4 as well, however metabolism to 14,15-LTE4 in these cells and tissue has not been documented. 14,15-LTE4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency than LTC4, but approximately 100-fold greater potency than histamine. |
Alias | 14,15-Leukotriene E4 |
Molecular Weight | 439.61 |
Formula | C23H37NO5S |
Cas No. | 1000852-57-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | Ethanol: > 50 mg/mL DMF: > 50 mg/mL DMSO: > 50 mg/mL PBS (pH 7.2): > 100μg/mL |
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