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Macrocyclic Compound Library

Catalog No. L9300
  Library Compound List   Excel SDF

Macrocyclic compounds are highly significant in drug and research development. When developing new drugs, macrocyclic compound are commonly researched in the medical field. Macrocyclic compounds are becoming more successfully recognised as an approach for low drug availability targets, such as antimicrobial, antiviral, and protein-protein interactions (PPIs). Topologically, macrocyclic compounds have a unique ability to span large surface areas whilst remaining conformationally restricted when compared to acyclic molecules of equivalent molecular weight. Macrocyclic compounds also reduce the overall polarity and enhance membrane permeability. Therefore, together these attributes make macrocycles a powerful approach for any lead discovery programme against challenging targets.

Research into macrocyclic compounds is increasing and are widely used in antibacterial, antiviral, and antitumor drugs for clinical applications. On antibacterial aspects, macrolides, cyclic peptides, aza-macrocyclic compounds, etc., for example, have the characteristics of broad antibacterial spectrum antibiotics. They also exhibit strong antibacterial activity, remarkable curative effect and circumvent drug resistance.

Clinical application of anti-herpes virus drugs, like ganciclovir and cidofovir have severe side effects with poor antiviral activity. Presently, attention is focused on research of naphthyridines. Some compounds already synthesised via computer technology are already exhibiting strong anti-herpes virus activity.

On anti-tumour aspects, epothilone has a similar mechanism of action as paclitaxel. Epothilone is highly toxic to cells that have developed resistance to paclitaxel, therefore overcomes the weakness displayed by paclitaxel.

With the continuous development of chemical synthesis technology, the discovery of macrocyclic lead compounds from natural products, improvement of the availability of genomic sequences and bioinformatics have marked the arrival of times of the exploration of new macrocyclic drugs. As research progresses macrocyclic drugs are sure to have a bright application prospect.

TargetMol’s Macrocyclic Compound Library collects 216 macrocyclic compounds of known activity for the study of macrocyclic drugs.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com
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Product Description

  • 216 macrocyclic compounds of known activity for high-throughput, high-content screening;
  • A powerful tool for studying antibacterial, antiviral, and protein-protein interactions, etc.;
  • Most of them are already approved, with information regarding biosafety and biological activity;
  • NMR and HPLC validated to ensure high purity and quality;
  • All compounds are available from stock supplies.

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L9300)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE