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GABAA receptor agent 6

Name: GABAA receptor agent 6
Brand: TargetMol
SKU: T60817
Price: 222 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T60817Cas No. 1808463-81-1

GABAA receptor agent 6 (compound 2027) is a potent γ-GABAAR antagonist with low cellular membrane permeability (Ki = 0.56 μM) [1].

GABAA receptor agent 6

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Catalog No. T60817Cas No. 1808463-81-1

GABAA receptor agent 6 (compound 2027) is a potent γ-GABAAR antagonist with low cellular membrane permeability (Ki = 0.56 μM) [1].

Pack Size	Price	Availability
25 mg	$1,520	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks

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Product Introduction

Bioactivity

Description	GABAA receptor agent 6 (compound 2027) is a potent γ-GABAAR antagonist with low cellular membrane permeability (Ki = 0.56 μM) [1].
In vitro	Compound 2027, a GABAA receptor agent, exhibits antagonist activity, with IC50 values of 6.68 μM for α1β2δ, 1.03 μM for α4β1δ, 0.36 μM for α4β2δ, 4.13 μM for α6β2δ, 4.96 μM for α1β2γ2, 2.96 μM for α2β2γ2, 0.29 μM for α3β2γ2, and 0.59 μM for α5β2γ2 subtypes, respectively [1].

Chemical Properties

Molecular Weight	315.41
Formula	C₁₈H₂₅N₃O₂
Cas No.	1808463-81-1

Storage & Solubility Information

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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