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AChE/Aβ-IN-1

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Catalog No. T79569

AChE/Aβ-IN-1 (compound 32) is a potent, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 86 nM and an NMDA receptor antagonist targeting the GluN1-1b/GluN2B subunit combination with an IC50 of 3.876 μM. It also impedes Aβ aggregation, exhibits favorable blood-brain barrier permeability, offers neuroprotection, and enhances cognitive and spatial memory in rat models [1].

AChE/Aβ-IN-1

AChE/Aβ-IN-1

😃Good
Catalog No. T79569
AChE/Aβ-IN-1 (compound 32) is a potent, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 86 nM and an NMDA receptor antagonist targeting the GluN1-1b/GluN2B subunit combination with an IC50 of 3.876 μM. It also impedes Aβ aggregation, exhibits favorable blood-brain barrier permeability, offers neuroprotection, and enhances cognitive and spatial memory in rat models [1].
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Product Introduction

Bioactivity
Description
AChE/Aβ-IN-1 (compound 32) is a potent, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 86 nM and an NMDA receptor antagonist targeting the GluN1-1b/GluN2B subunit combination with an IC50 of 3.876 μM. It also impedes Aβ aggregation, exhibits favorable blood-brain barrier permeability, offers neuroprotection, and enhances cognitive and spatial memory in rat models [1].
In vitro
AChE/Aβ-IN-1 (compound 32) inhibits the aggregation of Aβ1-42 (10 μM) at concentrations of 5-20 μM over 48 hours [1].
In vivo
Compound 32, designated as AChE/Aβ-IN-1, at a dosage of 10 mg/kg/day administered orally for 7 days, mitigated memory deficits in rats induced by Aβ1-42 and decreased the time spent in the platform area of the Morris Water Maze [1].
Chemical Properties
Molecular Weight401.34
FormulaC20H25BrN4
Storage & Solubility Information
StorageShipping with blue ice.

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