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PB2

Name: PB2
Brand: TargetMol
SKU: T35889
Price: 28 EUR
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T35889Cas No. 914940-24-2

PB2, a tris(2-carboxyethyl)phosphine (TCEP) analogue, enhances the survival of retinal ganglion cells (RGCs) following axotomy in vitro. Even at nanomolar and picomolar concentrations, PB2 demonstrates pronounced efficacy in promoting RGC survival. Notably, PB2 exhibits superior permeability compared to TCEP. Serving as a potent reducing agent, PB2 provides robust neuroprotection for RGCs[1].

PB2

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Catalog No. T35889Cas No. 914940-24-2

Pack Size	Price	Availability
2 mg	$95	5 days
5 mg	$178	7-10 days
10 mg	$347	7-10 days
1 mL x 10 mM (in DMSO)	$178	7-10 days

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Product Introduction

Bioactivity

Description	PB2, a tris(2-carboxyethyl)phosphine (TCEP) analogue, enhances the survival of retinal ganglion cells (RGCs) following axotomy in vitro. Even at nanomolar and picomolar concentrations, PB2 demonstrates pronounced efficacy in promoting RGC survival. Notably, PB2 exhibits superior permeability compared to TCEP. Serving as a potent reducing agent, PB2 provides robust neuroprotection for RGCs[1].
In vitro	PB2 (0.001~100000 nM; 72 hours; RGCs) increases RGC viability[1]. PB2's modifications neutralize compound polarity, and its methyl esters are likely cleaved by cytosolic esterases, producing a polar intracellular intermediate that is unlikely to cross cell membranes[1].

Chemical Properties

Molecular Weight	286.12
Formula	C₁₆H₂₀BO₂P
Cas No.	914940-24-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (349.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4950 mL	17.4752 mL	34.9504 mL	174.7519 mL
5 mM	0.6990 mL	3.4950 mL	6.9901 mL	34.9504 mL
10 mM	0.3495 mL	1.7475 mL	3.4950 mL	17.4752 mL
20 mM	0.1748 mL	0.8738 mL	1.7475 mL	8.7376 mL
50 mM	0.0699 mL	0.3495 mL	0.6990 mL	3.4950 mL
100 mM	0.0350 mL	0.1748 mL	0.3495 mL	1.7475 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PB2PB 2PB-2