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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $95 | 5 days | |
5 mg | $178 | 7-10 days | |
10 mg | $347 | 7-10 days | |
1 mL x 10 mM (in DMSO) | $178 | 7-10 days |
Description | PB2, a tris(2-carboxyethyl)phosphine (TCEP) analogue, enhances the survival of retinal ganglion cells (RGCs) following axotomy in vitro. Even at nanomolar and picomolar concentrations, PB2 demonstrates pronounced efficacy in promoting RGC survival. Notably, PB2 exhibits superior permeability compared to TCEP. Serving as a potent reducing agent, PB2 provides robust neuroprotection for RGCs[1]. |
In vitro | PB2 (0.001~100000 nM; 72 hours; RGCs) increases RGC viability[1].PB2 has modifications that neutralize the polarity of the compounds. The methylesters of PB2 is likely to be cleaved by cytosolic esterases, yielding a polar intracellular intermediate that would be unlikely to cross cell membranes[1]. |
Molecular Weight | 286.12 |
Formula | C16H20BO2P |
Cas No. | 914940-24-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (349.52 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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