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Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory properties. Upon ophthalmic administration, bromfenac binds to and inhibits cyclooxygenase II (COX II), an enzyme that converts arachidonic acid to cyclic endoperoxides, which are prostaglandin (PG) precursors. By inhibiting PG formation, bromfenac prevents PG-induced inflammation, vasodilation, leukocytosis, disruption of the blood-aqueous humor barrier, increased vascular permeability, and elevated intraocular pressure (IOP).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $30 | In Stock | |
25 mg | $38 | In Stock | |
50 mg | $48 | In Stock | |
100 mg | $74 | In Stock | |
500 mg | $178 | In Stock | |
1 mL x 10 mM (in DMSO) | $30 | In Stock |
Description | Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory properties. Upon ophthalmic administration, bromfenac binds to and inhibits cyclooxygenase II (COX II), an enzyme that converts arachidonic acid to cyclic endoperoxides, which are prostaglandin (PG) precursors. By inhibiting PG formation, bromfenac prevents PG-induced inflammation, vasodilation, leukocytosis, disruption of the blood-aqueous humor barrier, increased vascular permeability, and elevated intraocular pressure (IOP). |
Targets&IC50 | COX-2:7.45 nM (IC50), COX-1:5.56 nM (IC50) |
Alias | Bromfenac sodium sesquihydrate, Bromfenac monosodium salt sesquihydrate |
Molecular Weight | 383.17 |
Formula | C15H12BrNO3·3/2H2O·Na |
Cas No. | 120638-55-3 |
Smiles | O.[Na+].Nc1c(CC([O-])=O)cccc1C(=O)c1ccc(Br)cc1 |
Relative Density. | 1.565 g/cm3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 12.5 mg/mL (32.62 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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