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Bromfenac sodium hydrate

🥰Excellent
Catalog No. T2403Cas No. 120638-55-3
Alias Bromfenac sodium sesquihydrate, Bromfenac monosodium salt sesquihydrate

Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory properties. Upon ophthalmic administration, bromfenac binds to and inhibits cyclooxygenase II (COX II), an enzyme that converts arachidonic acid to cyclic endoperoxides, which are prostaglandin (PG) precursors. By inhibiting PG formation, bromfenac prevents PG-induced inflammation, vasodilation, leukocytosis, disruption of the blood-aqueous humor barrier, increased vascular permeability, and elevated intraocular pressure (IOP).

Bromfenac sodium hydrate

Bromfenac sodium hydrate

🥰Excellent
Purity: 99.65%
Catalog No. T2403Alias Bromfenac sodium sesquihydrate, Bromfenac monosodium salt sesquihydrateCas No. 120638-55-3
Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory properties. Upon ophthalmic administration, bromfenac binds to and inhibits cyclooxygenase II (COX II), an enzyme that converts arachidonic acid to cyclic endoperoxides, which are prostaglandin (PG) precursors. By inhibiting PG formation, bromfenac prevents PG-induced inflammation, vasodilation, leukocytosis, disruption of the blood-aqueous humor barrier, increased vascular permeability, and elevated intraocular pressure (IOP).
Pack SizePriceAvailabilityQuantity
10 mg$30In Stock
25 mg$38In Stock
50 mg$48In Stock
100 mg$74In Stock
500 mg$178In Stock
1 mL x 10 mM (in DMSO)$30In Stock
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Purity:99.65%
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Product Introduction

Bioactivity
Description
Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory properties. Upon ophthalmic administration, bromfenac binds to and inhibits cyclooxygenase II (COX II), an enzyme that converts arachidonic acid to cyclic endoperoxides, which are prostaglandin (PG) precursors. By inhibiting PG formation, bromfenac prevents PG-induced inflammation, vasodilation, leukocytosis, disruption of the blood-aqueous humor barrier, increased vascular permeability, and elevated intraocular pressure (IOP).
Targets&IC50
COX-2:7.45 nM (IC50), COX-1:5.56 nM (IC50)
AliasBromfenac sodium sesquihydrate, Bromfenac monosodium salt sesquihydrate
Chemical Properties
Molecular Weight383.17
FormulaC15H12BrNO3·3/2H2O·Na
Cas No.120638-55-3
SmilesO.[Na+].Nc1c(CC([O-])=O)cccc1C(=O)c1ccc(Br)cc1
Relative Density.1.565 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 12.5 mg/mL (32.62 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6098 mL13.0490 mL26.0981 mL130.4904 mL
5 mM0.5220 mL2.6098 mL5.2196 mL26.0981 mL
10 mM0.2610 mL1.3049 mL2.6098 mL13.0490 mL
20 mM0.1305 mL0.6525 mL1.3049 mL6.5245 mL

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