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Indomethacin sodium hydrate
🥰Excellent
Catalog No. T22346Cas No. 74252-25-8
Alias Indometacin sodium hydrate
Indomethacin sodium hydrate (Indometacin sodium hydrate) is an orally active, competitive and reversible COX1/2 inhibitor with potential anti-inflammatory activity in induced migraines, induced gastrointestinal injuries, and may be used in studies of increased intracranial pressure secondary to severe traumatic brain injury and rheumatoid arthritis in adults.
Indomethacin sodium hydrate
🥰Excellent
Purity: 99.45%
Catalog No. T22346Alias Indometacin sodium hydrateCas No. 74252-25-8
Indomethacin sodium hydrate (Indometacin sodium hydrate) is an orally active, competitive and reversible COX1/2 inhibitor with potential anti-inflammatory activity in induced migraines, induced gastrointestinal injuries, and may be used in studies of increased intracranial pressure secondary to severe traumatic brain injury and rheumatoid arthritis in adults.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 mg | 38 € | In Stock | |
| 1 g | 45 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 37 € | In Stock |
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CitedSelect Batch
Purity:99.45%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Indomethacin sodium hydrate (Indometacin sodium hydrate) is an orally active, competitive and reversible COX1/2 inhibitor with potential anti-inflammatory activity in induced migraines, induced gastrointestinal injuries, and may be used in studies of increased intracranial pressure secondary to severe traumatic brain injury and rheumatoid arthritis in adults. |
| In vitro | In 3LL-D122 cells, Indomethacin sodium hydrate (0, 20, 50, 100, and 150 μM; 24 hours) inhibited cell viability, with inhibition observed at 20 mM and 50% inhibition at 60 mM[2]. |
| In vivo | In male Sprague-Dawley rats, Indomethacin sodium hydrate (0.01-10 mg/kg; oral administration; for 3 hours) inhibited carrageenan-induced paw edema and hyperalgesia in a dose-dependent manner, with an ED50 of 2.0 mg/kg for paw edema and 1.5 mg/kg for hyperalgesia[1]. |
| Alias | Indometacin sodium hydrate |
| Molecular Weight | 433.82 |
| Formula | C19H21ClNNaO7 |
| Cas No. | 74252-25-8 |
| Smiles | O=C([O-])CC1=C(N(C2=C1C=C(OC)C=C2)C(C3=CC=C(Cl)C=C3)=O)C.[Na+].O.O.O |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store under nitrogen,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (11.52 mM), Sonification is recommended. H2O: 20 mg/mL (46.10 mM), Sonification is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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