Shopping Cart
- Remove All
![TargetMol](https://www.targetmol.com/storage/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 mg | $40 | In Stock | |
1 g | $48 | In Stock | |
1 mL x 10 mM (in DMSO) | $39 | In Stock |
Description | Indomethacin sodium hydrate (Indometacin sodium hydrate) is an orally active, competitive and reversible COX1/2 inhibitor with potential anti-inflammatory activity in induced migraines, induced gastrointestinal injuries, and may be used in studies of increased intracranial pressure secondary to severe traumatic brain injury and rheumatoid arthritis in adults. |
In vitro | In 3LL-D122 cells, Indomethacin sodium hydrate (0, 20, 50, 100, and 150 μM; 24 hours) inhibited cell viability, with inhibition observed at 20 mM and 50% inhibition at 60 mM[2]. |
In vivo | In male Sprague-Dawley rats, Indomethacin sodium hydrate (0.01-10 mg/kg; oral administration; for 3 hours) inhibited carrageenan-induced paw edema and hyperalgesia in a dose-dependent manner, with an ED50 of 2.0 mg/kg for paw edema and 1.5 mg/kg for hyperalgesia[1]. |
Alias | Indometacin sodium hydrate |
Molecular Weight | 433.82 |
Formula | C19H21ClNNaO7 |
Cas No. | 74252-25-8 |
Storage | store under nitrogen,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 5 mg/mL (11.52 mM) H2O: 20 mg/mL (46.10 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
H2O
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.