N,N-Dimethylacetamide

Name: N,N-Dimethylacetamide
Brand: TargetMol
SKU: T19439
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19439Cas No. 127-19-5

Alias DMAc

N,N-Dimethylacetamide (DMAc) is a drug excipient with blood-brain barrier permeability and anti-inflammatory activity, acting through inhibition of the NF-κB signaling pathway. N,N-Dimethylacetamide can reduce endotoxin-induced inflammatory responses in vivo.

N,N-Dimethylacetamide

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Catalog No. T19439Alias DMAcCas No. 127-19-5

Pack Size	Price	Availability	Quantity
500 mg	$34	In Stock
1 g	$48	In Stock

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Product Introduction

Bioactivity

Description	N,N-Dimethylacetamide (DMAc) is a drug excipient with blood-brain barrier permeability and anti-inflammatory activity, acting through inhibition of the NF-κB signaling pathway. N,N-Dimethylacetamide can reduce endotoxin-induced inflammatory responses in vivo.
In vitro	Methods: RAW 264.7 cells were treated with N,N-Dimethylacetamide (0-1000μM), and cell viability was determined by MTT assay. Results: N,N-Dimethylacetamide inhibited the bactericidal activity of macrophages in RAW 264.7 cells.[1]
In vivo	Methods: N,N-Dimethylacetamide (0.2, 0.39, 0.78, 1.56, 3.1 mg/kg, intraperitoneal injection) was used to treat LPS-induced C57BL/6 embryonic day (E) 15.5 mice. Results: N,N-Dimethylacetamide prevented LPS-triggered premature birth in C57BL/6 embryonic day (E) 15.5 mice in a concentration-dependent manner.[1]
Alias	DMAc

Chemical Properties

Molecular Weight	87.12
Formula	C₄H₉NO
Cas No.	127-19-5
Smiles	O=C(N(C)C)C
Relative Density.	0.94 g/cm3. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (918.27 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	11.4784 mL	57.3921 mL	114.7842 mL	573.9210 mL
5 mM	2.2957 mL	11.4784 mL	22.9568 mL	114.7842 mL
10 mM	1.1478 mL	5.7392 mL	11.4784 mL	57.3921 mL
20 mM	0.5739 mL	2.8696 mL	5.7392 mL	28.6961 mL
50 mM	0.2296 mL	1.1478 mL	2.2957 mL	11.4784 mL
100 mM	0.1148 mL	0.5739 mL	1.1478 mL	5.7392 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc