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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $39 | In Stock | |
5 mg | $80 | In Stock | |
10 mg | $128 | In Stock | |
25 mg | $263 | In Stock | |
50 mg | $393 | In Stock | |
100 mg | $576 | In Stock |
Description | Larazotide acetate is a synthetic peptide. It functions as a tight junction regulator and reverses leaky junctions to their normally closed state. |
In vitro | Larazotide acetate inhibits the AT-1002-induced TEER reduction and TJ opening in Caco-2 cells and it also inhibits the redistribution and rearrangement of zonula occludens-1 (ZO-1) and actin caused by AT-1002 and gliadin fragments in Caco-2 and IEC6 cells. Larazotide acetate inhibits the translocation of a gliadin 13-mer peptide, which has been implicated in celiac disease, across Caco-2 cell monolayers. Apically applied Larazotide acetate inhibits the increase in TJ permeability elicited by basolaterally applied cytokines. |
In vivo | Larazotide acetate inhibits gliadin-induced macrophage accumulation in the intestine and preserved normal tight junction structure when tested in vivo in gliadin-sensitized HLA-HCD4/DQ8 double transgenic mice. |
Molecular Weight | 785.89 |
Formula | C34H59N9O12 |
Cas No. | 881851-50-9 |
Storage | keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 16.67 mg/mL (21.21 mM) DMSO: 3.2 mg/mL (4.07 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
H2O
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