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Gap19
🥰Excellent
Catalog No. TP1563Cas No. 1507930-57-5
Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.
Gap19
🥰Excellent
Purity: 97.67%
Catalog No. TP1563Cas No. 1507930-57-5
Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $52 | In Stock | |
| 2 mg | $76 | In Stock | |
| 5 mg | $125 | In Stock | |
| 10 mg | $195 | In Stock | |
| 25 mg | $377 | In Stock | |
| 50 mg | $552 | In Stock | |
| 100 mg | $787 | In Stock |
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Purity:97.67%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43. |
| In vitro | Hemichannel inhibition is due to the binding of Gap19 to the C-terminus (CT) thereby preventing intramolecular CT-CL interactions.?The peptide inhibited Cx43 hemichannel unitary currents in both HeLa cells exogenously expressing Cx43 and acutely isolated pig ventricular cardiomyocytes.?Treatment with Gap19 prevented metabolic inhibition-enhanced hemichannel openings, protected cardiomyocytes against volume overload and cell death following ischemia/reperfusion in vitro and modestly decreased the infarct size after myocardial ischemia/reperfusion in mice in vivo[2]. |
| Molecular Weight | 1161.44 |
| Formula | C55H96N14O13 |
| Cas No. | 1507930-57-5 |
| Smiles | [C@@H](CC1=CC=CC=C1)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCCN)N)=O)CCC(N)=O)=O)[C@H](CC)C)=O)CCC(O)=O)=O)[C@H](CC)C)=O)CCCCN)=O)CCCCN)=O)C(N[C@@H](CCCCN)C(O)=O)=O |
| Relative Density. | 1.212 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | H2O: 5 mM DMSO: Insoluble | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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