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Gap19
Catalog No. TP1563Cas No. 1507930-57-5
Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $52 | In Stock | |
| 2 mg | $76 | In Stock | |
| 5 mg | $125 | In Stock | |
| 10 mg | $195 | In Stock | |
| 25 mg | $377 | In Stock | |
| 50 mg | $552 | In Stock | |
| 100 mg | $787 | In Stock |
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Questions
View MoreInhibitors Related to "Gap19"
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Rotigaptide TFA(355151-12-1 free base)
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Rotigaptide TFA(355151-12-1 free base) is a novel and specific modulator of Cx43 and is a potent AAP. Rotigaptide TFA(355151-12-1 free base) prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress.
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Gap 27
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Gap 26
Cited
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CitedTAT-Gap19 acetate
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TAT-Gap19 acetate is a specific inhibitor of connexin43 hemichannel (Cx43 HC). TAT-Gap19 acetate traverses the blood-brain barrier and alleviates liver fibrosis in mice. TAT-Gap19 acetate does not inhibit the corresponding Cx43 GJCs.
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Carbenoxolone
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Carbenoxolone disodium Cited
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Carbenoxolone disodium (Duogastrone) salt is an agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise, the drug is low in toxicity.
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CitedMeclofenamic acid
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Meclofenamic acid (Meclofenamate) is a non-selective gap-junction blocker and a selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic acid has anti-inflammatory activities.
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Danegaptide Hydrochloride
T19335943133-81-1
Danegaptide Hydrochloride (GAP-134 (Hydrochloride)) (GAP-134 Hydrochloride) is a selective modifier of the gap junction protein.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43. |
| In vitro | Hemichannel inhibition is due to the binding of Gap19 to the C-terminus (CT) thereby preventing intramolecular CT-CL interactions.?The peptide inhibited Cx43 hemichannel unitary currents in both HeLa cells exogenously expressing Cx43 and acutely isolated pig ventricular cardiomyocytes.?Treatment with Gap19 prevented metabolic inhibition-enhanced hemichannel openings, protected cardiomyocytes against volume overload and cell death following ischemia/reperfusion in vitro and modestly decreased the infarct size after myocardial ischemia/reperfusion in mice in vivo[2]. |
| Molecular Weight | 1161.44 |
| Formula | C55H96N14O13 |
| Cas No. | 1507930-57-5 |
| Storage | keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 5 mM DMSO: Insoluble | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O
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