Shopping Cart
- Remove All
Your shopping cart is currently empty
Gap 27
Catalog No. TP1333Cas No. 198284-64-9
Gap 27 is a peptide(Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile) derived from connexin 43 that is a selective gap junction blocker.
Gap 27
Catalog No. TP1333Cas No. 198284-64-9
Gap 27 is a peptide(Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile) derived from connexin 43 that is a selective gap junction blocker.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $48 | In Stock | |
| 5 mg | $97 | In Stock | |
| 10 mg | $141 | In Stock | |
| 25 mg | $236 | In Stock | |
| 50 mg | $352 | In Stock | |
| 100 mg | $528 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Gap 27"
Meclofenamic acid sodium
Movens, Meclonax, Meclomen, Meclofenamate Sodium
T02606385-02-0
Meclofenamic acid sodium (Movens), a non-steroidal anti-inflammatory agent, has properties of antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.
- $33
Size
QTY
Carbenoxolone disodium
Cited
Duogastrone, Bioral, Biogastrone
T09927421-40-1
Carbenoxolone disodium (Duogastrone) salt is an agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise, the drug is low in toxicity.
- $32
Size
QTY
CitedCarvedilol phosphate hemihydrate
Carvedilol phosphate, BM 14190 (phosphate hemihydrate)
T0342610309-89-2
Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and no intrinsic sympathomimetic activity.
- $31
Size
QTY
Rotigaptide TFA(355151-12-1 free base)
Rotigaptide TFA
T16790L
Rotigaptide TFA(355151-12-1 free base) is a novel and specific modulator of Cx43 and is a potent AAP. Rotigaptide TFA(355151-12-1 free base) prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress.
- $81
Size
QTY
TAT-Gap19 acetate
TP2110L
TAT-Gap19 acetate is a specific inhibitor of connexin43 hemichannel (Cx43 HC). TAT-Gap19 acetate traverses the blood-brain barrier and alleviates liver fibrosis in mice. TAT-Gap19 acetate does not inhibit the corresponding Cx43 GJCs.
- $58
Size
QTY
Gap19
TP15631507930-57-5
Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.
- $52
Size
QTY
Gap 26 Cited
T5192197250-15-0
Gap 26 is a mimetic peptide corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker.
- $79
Size
QTY
CitedLarazotide acetate
T15711881851-50-9
Larazotide acetate is a synthetic peptide. It functions as a tight junction regulator and reverses leaky junctions to their normally closed state.
- $39
Size
QTY
Danegaptide Hydrochloride
ZP 1609 Hydrochloride, GAP-134 (Hydrochloride)
T19335943133-81-1
Danegaptide Hydrochloride (GAP-134 (Hydrochloride)) (GAP-134 Hydrochloride) is a selective modifier of the gap junction protein.
- $47
Size
QTY
Carbenoxolone
Carbenoxolone, Carbenoxolona, Bioral, Biogastrone
T77325697-56-3
Carbenoxolone (Biogastrone) is an inhibitor of 11β-HSD and gap junction connexin channels. Carbenoxolone inhibits macrophage migration into atria and prevents the development of fatty liver disease.
- $50
Size
QTY
Select Batch
Purity:100%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Gap 27 is a peptide(Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile) derived from connexin 43 that is a selective gap junction blocker. |
| In vitro | Gap 27 significantly reduces the population of TRAP-positive mononuclear and multinucleated rat osteoclasts on bovine bone slices and decreases the functionality of remaining osteoclasts, as demonstrated by a lower percentage of osteoclasts displaying actin rings among all TRAP-positive cells. Moreover, the area resorbed by these treated cultures is substantially reduced[1]. When applied to the carotid artery, Gap 27 at a concentration of 500 μM effectively eliminates the hyperpolarization response to acetylcholine, but does not affect the response to levcromakalim, indicating a specific inhibition of acetylcholine-induced, endothelium-dependent hyperpolarizations in the guinea-pig-isolated internal carotid artery[2]. |
| In vivo | Gap 27 (300 μM) inhibits relaxation by 40% in thoracic aorta and the superior mesenteric artery. Gap 27 also attenuates the endothelium-dependent component of the relaxation induced by ATP in thoracic aorta but did not modify force development in response to PhE[3]. |
| Molecular Weight | 1304.53 |
| Formula | C60H101N15O17 |
| Cas No. | 198284-64-9 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: Insoluble H2O: 10 mM | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
H2O
| |||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Gap 27 | purchase Gap 27 | Gap 27 cost | order Gap 27 | Gap 27 chemical structure | Gap 27 in vivo | Gap 27 in vitro | Gap 27 formula | Gap 27 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.