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Antifungal agent 106
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Catalog No. T89311
Antifungalagent 106 (Compound Z31) is a benzoic acid derivative and a potential fungicide targeting Monilinia fructicola. It exhibits antifungal activity with an EC50 of 11.8 mg/L. The mechanism of action involves the disruption of cell membrane integrity, resulting in increased membrane permeability and the release of intracellular electrolytes, which impairs normal mycelial growth. Antifungalagent 106 is also applicable in research related to brown rot in stone fruits.
Antifungal agent 106
Antifungal agent 106
😃Good
Catalog No. T89311
Antifungalagent 106 (Compound Z31) is a benzoic acid derivative and a potential fungicide targeting Monilinia fructicola. It exhibits antifungal activity with an EC50 of 11.8 mg/L. The mechanism of action involves the disruption of cell membrane integrity, resulting in increased membrane permeability and the release of intracellular electrolytes, which impairs normal mycelial growth. Antifungalagent 106 is also applicable in research related to brown rot in stone fruits.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Antifungalagent 106 (Compound Z31) is a benzoic acid derivative and a potential fungicide targeting Monilinia fructicola. It exhibits antifungal activity with an EC50 of 11.8 mg/L. The mechanism of action involves the disruption of cell membrane integrity, resulting in increased membrane permeability and the release of intracellular electrolytes, which impairs normal mycelial growth. Antifungalagent 106 is also applicable in research related to brown rot in stone fruits. |
| Targets&IC50 | mTOR:0.8 μM |
| In vitro | Antifungal agent 106, at concentrations ranging from 3.125 to 50 mg/L, demonstrates inhibitory effects on M. fructicola by suppressing spore germination and mycelial formation. It induces cellular oxidative damage, enzyme inactivation, and cell membrane disruption in M. fructicola by prompting the overproduction of reactive oxygen species (ROS). |
| In vivo | When plants (pear) were treated with Antifungal agent 106 at concentrations of 100 mg/L and 200 mg/L and sprayed over a 24-hour period, they exhibited significantly lower incidence rates of brown rot and smaller lesion diameters, indicating that Antifungal agent 106 has inhibitory activity against brown rot in stone fruits. |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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