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MAO-B-IN-21

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Catalog No. T74860Cas No. 2956426-18-7

MAO-B-IN-21 is an MAO-B inhibitor characterized by superior antioxidant and anti-Aβ aggregation activities, metal-ion chelating capabilities, and mitigation of neuroinflammation (NO, TNF-α). It demonstrates neuroprotective effects with notable BBB permeability and, in an Aβ1-42 induced Alzheimer's disease mouse model, significantly enhances memory and cognitive functions [1].

MAO-B-IN-21

MAO-B-IN-21

😃Good
Catalog No. T74860Cas No. 2956426-18-7
MAO-B-IN-21 is an MAO-B inhibitor characterized by superior antioxidant and anti-Aβ aggregation activities, metal-ion chelating capabilities, and mitigation of neuroinflammation (NO, TNF-α). It demonstrates neuroprotective effects with notable BBB permeability and, in an Aβ1-42 induced Alzheimer's disease mouse model, significantly enhances memory and cognitive functions [1].
Pack SizePriceAvailabilityQuantity
25 mg$1,5206-8 weeks
50 mg$1,9806-8 weeks
100 mg$2,5006-8 weeks
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Product Introduction

Bioactivity
Description
MAO-B-IN-21 is an MAO-B inhibitor characterized by superior antioxidant and anti-Aβ aggregation activities, metal-ion chelating capabilities, and mitigation of neuroinflammation (NO, TNF-α). It demonstrates neuroprotective effects with notable BBB permeability and, in an Aβ1-42 induced Alzheimer's disease mouse model, significantly enhances memory and cognitive functions [1].
In vitro
MAO-B-IN-21 at a concentration of 37.5 μM in a methanol solution (甲醇溶液) inhibits Cu2+-induced ROS production due to its metal chelating properties and/or its antioxidant capacity, capable of scavenging free radicals from the Cu2+-ascorbic acid redox system [1]. Additionally, MAO-B-IN-21 at 25 μM for 24 hours at 37℃ suppresses the self-induced aggregation of Aβ1-42 and disassembles preformed Aβ1-42 fibrils [1]. Furthermore, MAO-B-IN-21 in a range of 2.5-25 μM over 24 hours inhibits the production of ROS in LPS-stimulated BV-2 microglial cells [1].
In vivo
MAO-B-IN-21 (30 mg/kg; ig; single dose) readily crosses the blood-brain barrier in Balb/C mice [1]. At 8 mg/kg and 32 mg/kg doses administered intragastrically, it reduces escape latency time (ELT) and decreases Aβ 1-42 levels, indicating potential improvements in learning and memory in an Aβ-induced Alzheimer's disease (AD) mouse model [1]. Pharmacokinetic analysis in Balb/C mice [1] shows the following parameters: Tissue T 1/2, T max, C max, AUC 0-t, and AUC brain/plasma ratio with plasma at 1.15 h, 0.5 h, 1539 ng/mL, 2941 ng·h/mL, 0.69, and brain at 2.07 h, 1.0 h, 922.7 ng/g, and 2032.5 ng·h/g, respectively.
Chemical Properties
Molecular Weight440.92
FormulaC24H25ClN2O4
Cas No.2956426-18-7
Storage & Solubility Information
StorageShipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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