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Polymyxin B
🥰Excellent
Catalog No. T78685Cas No. 1404-26-8
Polymyxin B is a polymyxin antibiotic with antimicrobial activity that acts by binding with high affinity to the LPS of the bacterial wall and by increasing the permeability of the bacterial cell membrane, and is used in the study of infections caused by drug-resistant (XDR) Gram-negative bacteria (GNB) Polymyxin B is used in the study of endotoxemia.
Polymyxin B
Polymyxin B
🥰Excellent
Catalog No. T78685Cas No. 1404-26-8
Polymyxin B is a polymyxin antibiotic with antimicrobial activity that acts by binding with high affinity to the LPS of the bacterial wall and by increasing the permeability of the bacterial cell membrane, and is used in the study of infections caused by drug-resistant (XDR) Gram-negative bacteria (GNB) Polymyxin B is used in the study of endotoxemia.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $34 | In Stock | |
| 50 mg | $46 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Polymyxin B is a polymyxin antibiotic with antimicrobial activity that acts by binding with high affinity to the LPS of the bacterial wall and by increasing the permeability of the bacterial cell membrane, and is used in the study of infections caused by drug-resistant (XDR) Gram-negative bacteria (GNB) Polymyxin B is used in the study of endotoxemia. |
| In vitro | 10 μg/mL Polymyxin B, treated for 6 hours, reduced TNF-α and IL-10 production in human peripheral blood mononuclear cells (PBMCs). [3] |
| In vivo | Polymyxin B was administered intravenously once daily for seven consecutive days at a dose range of 5-20 mg/kg Polymyxin B. The treatment of PBMCs with Polymyxin B for six hours reduced TNF-α and IL-10 production. A nephrotoxicity endpoint was observed in the Sprague-Dawley rat model at the 20 mg/kg dose, whereas no such endpoint was observed at the 5 mg/kg dose. [2] |
| Cas No. | 1404-26-8 |
Storage & Solubility Information
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O: 30 mg/mL, Adjust pH to 2 and sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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