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Polyethylene glycol 12-hydroxystearate (Solutol HS-15) is a permeability enhancer.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 g | $30 | In Stock | |
10 g | $41 | In Stock |
Description | Polyethylene glycol 12-hydroxystearate (Solutol HS-15) is a permeability enhancer. |
In vitro | Polyethylene glycol 12-hydroxystearate promotes the apical-to-basolateral translocation of a model protein (insulin) across Calu-3 monolayers when applied at 37°C. Furthermore there is no statistically significant increase in insulin permeability in the presence of Polyethylene glycol 12-hydroxystearate, relative to the respective control, at 4°C. Polyethylene glycol 12-hydroxystearate treated cells show a statistically significant increase in permeability towards lower molecular weight permeants (5 to 22 kDa) and an absence of a statistically significant increase in permeability of proteins with larger molecular weight, namely albumin and IgG (P>0.05 relative to control). |
Alias | Solutol HS-15 |
Molecular Weight | 344.536 |
Formula | C20H40O4 |
Cas No. | 61909-81-7 |
Smiles | N.CCCCCCC(O)CCCCCCCCCCC(=O)OCCO |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | Ethanol: 100 mg/mL, Sonication is recommended. H2O: 25 mg/mL, Sonication is recommended. |
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