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Polyethylene glycol 12-hydroxystearate
Catalog No. T19562Cas No. 61909-81-7
Alias Solutol HS-15
Polyethylene glycol 12-hydroxystearate (Solutol HS-15) is a permeability enhancer.
Polyethylene glycol 12-hydroxystearate
Catalog No. T19562Alias Solutol HS-15Cas No. 61909-81-7
Polyethylene glycol 12-hydroxystearate (Solutol HS-15) is a permeability enhancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 g | $30 | In Stock | |
| 10 g | $41 | In Stock |
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Purity:98%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Polyethylene glycol 12-hydroxystearate (Solutol HS-15) is a permeability enhancer. |
| In vitro | Polyethylene glycol 12-hydroxystearate promotes the apical-to-basolateral translocation of a model protein (insulin) across Calu-3 monolayers when applied at 37°C. Furthermore there is no statistically significant increase in insulin permeability in the presence of Polyethylene glycol 12-hydroxystearate, relative to the respective control, at 4°C. Polyethylene glycol 12-hydroxystearate treated cells show a statistically significant increase in permeability towards lower molecular weight permeants (5 to 22 kDa) and an absence of a statistically significant increase in permeability of proteins with larger molecular weight, namely albumin and IgG (P>0.05 relative to control). |
| Alias | Solutol HS-15 |
| Molecular Weight | 344.536 |
| Formula | C20H40O4 |
| Cas No. | 61909-81-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol: 100 mg/mL, Sonication is recommended. H2O: 25 mg/mL, Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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