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Polyethylene glycol 12-hydroxystearate

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COA HNMR

Polyethylene glycol 12-hydroxystearate

Catalog No. T19562Cas No. 61909-81-7

Polyethylene glycol 12-hydroxystearate (Solutol HS-15) is a permeability enhancer.

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Pack Size	Price	Availability	Quantity
5 g	$30	In Stock
10 g	$41	In Stock

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Product Introduction

Bioactivity

Description	Polyethylene glycol 12-hydroxystearate (Solutol HS-15) is a permeability enhancer.
In vitro	Polyethylene glycol 12-hydroxystearate promotes the apical-to-basolateral translocation of a model protein (insulin) across Calu-3 monolayers when applied at 37°C. Furthermore there is no statistically significant increase in insulin permeability in the presence of Polyethylene glycol 12-hydroxystearate, relative to the respective control, at 4°C. Polyethylene glycol 12-hydroxystearate treated cells show a statistically significant increase in permeability towards lower molecular weight permeants (5 to 22 kDa) and an absence of a statistically significant increase in permeability of proteins with larger molecular weight, namely albumin and IgG (P>0.05 relative to control).
Alias	Solutol HS-15

Chemical Properties

Molecular Weight	344.536
Formula	C20H40O4
Cas No.	61909-81-7

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	Ethanol: 100 mg/mL, Sonication is recommended. H2O: 25 mg/mL, Sonication is recommended.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Polyethylene glycol 12-hydroxystearateInhibitorinhibitSolutolPolyethylene glycol 12 hydroxystearatePolyethylene glycol 12hydroxystearateHS-15

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