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NIM811

Name: NIM811
Brand: TargetMol
SKU: T12226
Price: 33 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T12226Cas No. 143205-42-9

Alias SDZ NIM811, (Melle-4)cyclosporin

NIM811 is an orally bioavailable dual inhibitor of mitochondrial permeability transition and cyclophilin.

NIM811

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Catalog No. T12226Alias SDZ NIM811, (Melle-4)cyclosporinCas No. 143205-42-9

NIM811 is an orally bioavailable dual inhibitor of mitochondrial permeability transition and cyclophilin.

Pack Size	Price	Availability	Quantity
5 mg	Inquiry	Backorder

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	NIM811 is an orally bioavailable dual inhibitor of mitochondrial permeability transition and cyclophilin.
In vitro	NIM811 is a useful alternative to PKF220-384 to investigate the role of the mitochondrial permeability transition in apoptotic and necrotic cell death[1].
Alias	SDZ NIM811, (Melle-4)cyclosporin

Chemical Properties

Molecular Weight	1202.635
Formula	C₆₂H₁₁₁N₁₁O₁₂
Cas No.	143205-42-9
Relative Density.	1.018g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (83.15 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8315 mL	4.1575 mL	8.3151 mL	41.5754 mL
5 mM	0.1663 mL	0.8315 mL	1.6630 mL	8.3151 mL
10 mM	0.0832 mL	0.4158 mL	0.8315 mL	4.1575 mL
20 mM	0.0416 mL	0.2079 mL	0.4158 mL	2.0788 mL
50 mM	0.0166 mL	0.0832 mL	0.1663 mL	0.8315 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SDZ NIM 811NIM811NIM-811NIM 811SDZ NIM-811