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Sulconazole mononitrate

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Purity:99.92%

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COA HNMR HPLC

Sulconazole mononitrate

Catalog No. T6686Cas No. 61318-91-0

Sulconazole mononitrate (Exelderm) is the nitrate salt form of sulconazole, a synthetic imidazole derivative with the antifungal property. Sulconazole mononitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols and inhibition of the synthesis of ergosterol, an important component of the fungal cell membrane. Inhibition of ergosterol synthesis leads to a disruption of cell membrane permeability, and ultimately inhibition of cell wall synthesis. In addition, Sulconazole mononitrate seems to interfere with the autolytic degradation of fungal DNA and RNA.

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Pack Size	Price	Availability
25 mg	$31	In Stock
50 mg	$46	In Stock
100 mg	$62	In Stock

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Product Introduction

Bioactivity

Description	Sulconazole mononitrate (Exelderm) is the nitrate salt form of sulconazole, a synthetic imidazole derivative with the antifungal property. Sulconazole mononitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols and inhibition of the synthesis of ergosterol, an important component of the fungal cell membrane. Inhibition of ergosterol synthesis leads to a disruption of cell membrane permeability, and ultimately inhibition of cell wall synthesis. In addition, Sulconazole mononitrate seems to interfere with the autolytic degradation of fungal DNA and RNA.
In vitro	Sulconazole mononitrate possesses a broad spectrum of activity in vitro against dermatophytes, yeasts and some Gram-positive bacteria at concentrations below 5 mg/L in vitro. It has been shown that against representatives of pathogenic yeasts, dermatophytes and Aspergilli, the RIF values of sulconazole are broadly similar to those of other imidazoles. The fungicidal potency of sulconazole in vitro depends on its concentration and on the growth phase of the inoculum cells. Sulconazole has also demonstrated antibacterial activity in vitro, with MIC values below 12.5 mg/L. [1]
In vivo	The efficacy and safety of sulconazole 1% cream has been demonstrated in controlled clinical studies in patients with superficial dermatophyte or yeast infections. To minimise the risk of reinfection treatment should continue for 3 weeks in Candida infections, tinea cruris, tinea corporis and pityriasis versicolor, and for 4 weeks in patients with tinea pedis. [1]
Alias	Exelderm, Sulconazole Nitrate, RS 44872

Chemical Properties

Molecular Weight	460.76
Formula	C18H15Cl3N2S·HNO3
Cas No.	61318-91-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 55 mg/mL (119.37 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1703 mL	10.8516 mL	21.7033 mL	108.5164 mL
5 mM	0.4341 mL	2.1703 mL	4.3407 mL	21.7033 mL
10 mM	0.2170 mL	1.0852 mL	2.1703 mL	10.8516 mL
20 mM	0.1085 mL	0.5426 mL	1.0852 mL	5.4258 mL
50 mM	0.0434 mL	0.2170 mL	0.4341 mL	2.1703 mL
100 mM	0.0217 mL	0.1085 mL	0.2170 mL	1.0852 mL

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