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S21-1011

Catalog No. T88213Cas No. 2671859-87-1

S21-1011 is a selective butyrylcholinesterase (BChE) inhibitor, demonstrating IC50 values of 0.059 μM for eqBChE and 0.162 μM for hBChE. This compound displays favorable pharmacokinetic properties, including effective blood-brain barrier (BBB) permeability. Furthermore, S21-1011 activates the keap1-Nrf2-ARE pathway, with an EC50 of 23.48 μM for activating the antioxidant element ARE, and has been shown to improve cognitive function in a murine model of Alzheimer’s disease.

S21-1011

S21-1011

Catalog No. T88213Cas No. 2671859-87-1
S21-1011 is a selective butyrylcholinesterase (BChE) inhibitor, demonstrating IC50 values of 0.059 μM for eqBChE and 0.162 μM for hBChE. This compound displays favorable pharmacokinetic properties, including effective blood-brain barrier (BBB) permeability. Furthermore, S21-1011 activates the keap1-Nrf2-ARE pathway, with an EC50 of 23.48 μM for activating the antioxidant element ARE, and has been shown to improve cognitive function in a murine model of Alzheimer’s disease.
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10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
S21-1011 is a selective butyrylcholinesterase (BChE) inhibitor, demonstrating IC50 values of 0.059 μM for eqBChE and 0.162 μM for hBChE. This compound displays favorable pharmacokinetic properties, including effective blood-brain barrier (BBB) permeability. Furthermore, S21-1011 activates the keap1-Nrf2-ARE pathway, with an EC50 of 23.48 μM for activating the antioxidant element ARE, and has been shown to improve cognitive function in a murine model of Alzheimer’s disease.
Targets&IC50
eqBCHE:0.059 μM, hBCHE:0.162 μM
Chemical Properties
Molecular Weight464.60
FormulaC30H32N4O
Cas No.2671859-87-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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