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SPR741 acetate

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Purity:98.57%

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COA HPLC MS

SPR741 acetate

Catalog No. T12992

SPR741 acetate is a cationic peptide derived from polymyxin B. It exhibits antimicrobial activity against gram-negative bacteria by inhibiting severe gram-negative bacterial sensory by increasing the permeability of the outer membrane of gram-negative bacteria.SPR741 acetate is often used in conjunction with antibiotics for the treatment of a number of diseases.

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Pack Size	Price	Availability
1 mg	$183	In Stock
5 mg	$465	In Stock
10 mg	$633	In Stock
25 mg	$987	In Stock
50 mg	$1,360	In Stock
100 mg	$1,830	In Stock

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Product Introduction

Bioactivity

Description	SPR741 acetate is a cationic peptide derived from polymyxin B. It exhibits antimicrobial activity against gram-negative bacteria by inhibiting severe gram-negative bacterial sensory by increasing the permeability of the outer membrane of gram-negative bacteria.SPR741 acetate is often used in conjunction with antibiotics for the treatment of a number of diseases.
In vitro	SPR741 acetate potentiates antibiotics ,SPR741 acetate are substrates of the AcrAB-TolC efflux pump in E. coli, effectively circumventing the contribution of this pump to intrinsic antibiotic resistance. The intrinsic resistance of E. coli to certain antibiotics that is mediated by both the outer membrane and the AcrAB-TolC efflux system can be overcome, or circumvented, by combining the antibiotic with SPR741 acetate but that potentiation of intrinsic resistance due primarily to efflux may be limited.[1]
In vivo	SPR741 acetate has the ability to permeabilize the outer membrane of Gram-negative bacteria, thus makeing them sensitive to hydrophobic antibiotics. SPR741 acetate has a significantly safety profile of compared to that of polymyxin B, which suffers severe, dose-limiting nephrotoxicity in humans. Polymyxin B exhibited nephrotoxicity at a far-lower exposure-normalized dose than SPR741 acetate in multiday rodent and nonhuman primate studies.[1]
Alias	SPR741 acetate, NAB741 acetate, SPR741 acetate (1179330-52-9 free base)

Chemical Properties

Molecular Weight	1052.18
Formula	C46H77N13O15
Cas No.

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 117.0 mg/mL (111.2 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9504 mL	4.7520 mL	9.5041 mL	47.5204 mL
5 mM	0.1901 mL	0.9504 mL	1.9008 mL	9.5041 mL
10 mM	0.0950 mL	0.4752 mL	0.9504 mL	4.7520 mL
20 mM	0.0475 mL	0.2376 mL	0.4752 mL	2.3760 mL
50 mM	0.0190 mL	0.0950 mL	0.1901 mL	0.9504 mL
100 mM	0.0095 mL	0.0475 mL	0.0950 mL	0.4752 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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