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NF-1819

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Purity:98.21%

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COA HNMR HPLC

NF-1819

Catalog No. T28165Cas No. 1881244-28-5

NF-1819 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. NF-1819 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model in vivo. NF-1819 displays high membrane permeability and brain penetrant.

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Pack Size	Price	Availability
5 mg	$58	In Stock
10 mg	$97	In Stock
25 mg	$198	In Stock
50 mg	$358	In Stock
100 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$58	In Stock

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Product Introduction

Bioactivity

Description	NF-1819 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. NF-1819 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model in vivo. NF-1819 displays high membrane permeability and brain penetrant.
Alias	NF 1819, NF1819

Chemical Properties

Molecular Weight	463.46
Formula	C24H22FN5O4
Cas No.	1881244-28-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (118.67 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1577 mL	10.7884 mL	21.5768 mL	107.8842 mL
5 mM	0.4315 mL	2.1577 mL	4.3154 mL	21.5768 mL
10 mM	0.2158 mL	1.0788 mL	2.1577 mL	10.7884 mL
20 mM	0.1079 mL	0.5394 mL	1.0788 mL	5.3942 mL
50 mM	0.0432 mL	0.2158 mL	0.4315 mL	2.1577 mL
100 mM	0.0216 mL	0.1079 mL	0.2158 mL	1.0788 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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