MAO-B-IN-22

Name: MAO-B-IN-22
Brand: TargetMol
SKU: T78907
Rating: 4.5 (1 reviews)

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Catalog No. T78907Cas No. 2902600-76-2

MAO-B-IN-22 (compound 6h) is a potent MAO-B inhibitor with an IC50 value of 0.014 μM, exhibiting significant antioxidant activity, effective metal-chelating properties, adequate BBB permeability, and notable neuroprotective effects [1].

MAO-B-IN-22

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Catalog No. T78907Cas No. 2902600-76-2

Pack Size	Price	Availability
25 mg	$1,520	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks

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Product Introduction

Bioactivity

Description	MAO-B-IN-22 (compound 6h) is a potent MAO-B inhibitor with an IC50 value of 0.014 μM, exhibiting significant antioxidant activity, effective metal-chelating properties, adequate BBB permeability, and notable neuroprotective effects [1].
In vitro	MAO-B-IN-22 (compound 6h) demonstrated dose-dependent protection against hydrogen peroxide-induced oxidative damage, enhancing cell viability at concentrations of 2.5 to 50 μM over 24 hours [1]. At lower concentrations of 0.5 to 10 μM, it reduced LPS-induced NO production in a dose-dependent manner, indicating anti-neuroinflammatory activity [1].
In vivo	MAO-B-IN-22 (compound 6h) (53.5 mg/kg, administered via oral gavage once daily for three weeks) can alleviate motor impairments in mice by inhibiting MAO-B, increasing dopaminergic neurotransmitter levels, and reducing oxidative damage caused by reactive oxygen species (ROS), potentially mitigating motor dysfunction induced by MPTP and improving symptoms of Parkinson's disease (PD) in vivo [1].

Chemical Properties

Molecular Weight	323.36
Formula	C₂₀H₁₈FNO₂
Cas No.	2902600-76-2

Storage & Solubility Information

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Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc