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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | MAO-B-IN-22 (compound 6h) is a potent MAO-B inhibitor with an IC50 value of 0.014 μM, exhibiting significant antioxidant activity, effective metal-chelating properties, adequate BBB permeability, and notable neuroprotective effects [1]. |
In vitro | MAO-B-IN-22 (compound 6h) demonstrated dose-dependent protection against hydrogen peroxide-induced oxidative damage, enhancing cell viability at concentrations of 2.5 to 50 μM over 24 hours [1]. At lower concentrations of 0.5 to 10 μM, it reduced LPS-induced NO production in a dose-dependent manner, indicating anti-neuroinflammatory activity [1]. |
In vivo | MAO-B-IN-22 (compound 6h) (53.5 mg/kg, administered via oral gavage once daily for three weeks) can alleviate motor impairments in mice by inhibiting MAO-B, increasing dopaminergic neurotransmitter levels, and reducing oxidative damage caused by reactive oxygen species (ROS), potentially mitigating motor dysfunction induced by MPTP and improving symptoms of Parkinson's disease (PD) in vivo [1]. |
Molecular Weight | 323.36 |
Formula | C20H18FNO2 |
Cas No. | 2902600-76-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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