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BACE1/2-IN-1
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BACE1/2-IN-1
Catalog No. T61956Cas No. 2671036-34-1
BACE1/2-IN-1 (compound 34) is an effective BACE1 and BACE2 inhibitor with IC50 of 0.01 and 0.0053 μM, respectively. BACE1/2-IN-1 has lower Pgp efflux ratio and improved passive permeability. The metabolic stability of BACE1/2-IN-1 in liver microsomes is decreased.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | BACE1/2-IN-1 (compound 34) is an effective BACE1 and BACE2 inhibitor with IC50 of 0.01 and 0.0053 μM, respectively. BACE1/2-IN-1 has lower Pgp efflux ratio and improved passive permeability. The metabolic stability of BACE1/2-IN-1 in liver microsomes is decreased. |
| In vitro | Compound 34, identified as BACE1/2-IN-1, exhibits a modest preference for BACE2 over BACE1, while maintaining a selectivity greater than 3000-fold when compared to Cathepsin D [1]. |
| In vivo | BACE1/2-IN-1 (compound 34) administered through subcutaneous injection at doses of 0-100 mg/kg once in PDAPP (V717F) transgenic mice, significantly reduces cortical Aβ levels by 40% at 100 mg/kg and 24% at 30 mg/kg, with no significant reduction (12%NS) observed at 10 mg/kg [1]. |
| Molecular Weight | 401.57 |
| Formula | C21H31N5OS |
| Cas No. | 2671036-34-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。 Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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