Shopping Cart

Remove All

Your shopping cart is currently empty

LCH-7749944

Select Batch

Purity:99.28%

Resource Download

COA HNMR HPLC

LCH-7749944

Catalog No. T11826Cas No. 796888-12-5

LCH-7749944 (GNF-PF-2356) is a potent PAK4 inhibitor with an IC50 of 14.93 μM, effectively suppressing the proliferation of human gastric cancer cells by downregulating the PAK4/c-Src/EGFR/cyclin D1 pathway and inducing apoptosis.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$75	In Stock
5 mg	$183	In Stock
10 mg	$278	In Stock
25 mg	$496	In Stock
50 mg	$745	In Stock
100 mg	$1,080	In Stock
1 mL x 10 mM (in DMSO)	$197	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "LCH-7749944"

Product Introduction

Bioactivity

Description	LCH-7749944 (GNF-PF-2356) is a potent PAK4 inhibitor with an IC50 of 14.93 μM, effectively suppressing the proliferation of human gastric cancer cells by downregulating the PAK4/c-Src/EGFR/cyclin D1 pathway and inducing apoptosis.
Targets&IC50	PAK4:14.93 μM
In vitro	LCH-7749944 (5-20 μM; 12-48 hours) prominently induces a dose-dependent increase in the percentage of cells in G1 phase and decrease in S phase. ?LCH-7749944 (5-30 μM; 24 hours) dramatically decreases levels of phosphoPAK4, phospho-c-Src, phospho-EGFR and cyclin D1 protein expression in a dose-dependent manner.?LCH-7749944 (GNF-PF-2356;?5-50 μM;?24 hours) inhibits the proliferation of MKN-1, BGC823, SGC7901 and MGC803 cells in a concentration dependent manner.??LCH-7749944 (5-20 μM;?12-48 hours) induces apoptosis of SGC7901 cells.
Alias	GNF-PF-2356

Chemical Properties

Molecular Weight	350.41
Formula	C20H22N4O2
Cas No.	796888-12-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 250 mg/mL (713.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8538 mL	14.2690 mL	28.5380 mL	142.6900 mL
5 mM	0.5708 mL	2.8538 mL	5.7076 mL	28.5380 mL
10 mM	0.2854 mL	1.4269 mL	2.8538 mL	14.2690 mL
20 mM	0.1427 mL	0.7134 mL	1.4269 mL	7.1345 mL
50 mM	0.0571 mL	0.2854 mL	0.5708 mL	2.8538 mL
100 mM	0.0285 mL	0.1427 mL	0.2854 mL	1.4269 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc