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BBO-8520

Name: BBO-8520
Brand: TargetMol
SKU: T85809
Rating: 4.5 (1 reviews)

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Catalog No. T85809Cas No. 2893809-51-1

BBO-8520 is an orally available direct small molecule covalent inhibitor that targets KRAS G12C. It functions as a KRAS G12C (OFF) inhibitor and blocks the KRAS G12C (ON) signal by binding to the GTP protein, thereby inhibiting cell proliferation. Additionally, BBO-8520 can disrupt the RAS-RAF1 interaction, returning KRAS G12C to its inactive (OFF) state [1].

BBO-8520

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Catalog No. T85809Cas No. 2893809-51-1

Pack Size	Price	Availability	Quantity
10 mg	Inquiry	10-14 weeks
50 mg	Inquiry	10-14 weeks

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Product Introduction

Bioactivity

Description	BBO-8520 is an orally available direct small molecule covalent inhibitor that targets KRAS G12C. It functions as a KRAS G12C (OFF) inhibitor and blocks the KRAS G12C (ON) signal by binding to the GTP protein, thereby inhibiting cell proliferation. Additionally, BBO-8520 can disrupt the RAS-RAF1 interaction, returning KRAS G12C to its inactive (OFF) state [1].
In vivo	BBO-8520 (10 mg/kg/d; po) inhibits pERK and KRAS G12C activation in the KrasG12C-p53 driven GEMM model, resulting in sustained tumor regression. Additionally, BBO-8520 demonstrates a strong dose- and time-dependent pharmacodynamic effect in KRASG12C mutant tumor-bearing mice, with pERK inhibition exceeding 80% [1].

Chemical Properties

Molecular Weight	729.74
Formula	C₃₅H₃₃F₆N₇O₂S
Cas No.	2893809-51-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc