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Poziotinib hydrochloride irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. It is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $50 | In Stock | |
10 mg | $75 | In Stock | |
25 mg | $128 | In Stock | |
50 mg | $192 | In Stock | |
100 mg | $287 | In Stock | |
200 mg | $431 | In Stock | |
500 mg | $713 | In Stock | |
1 mL x 10 mM (in DMSO) | $81 | In Stock |
Description | Poziotinib hydrochloride irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. It is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity. |
Alias | NOV120101 hydrochloride, HM 781-36B hydrochloride |
Molecular Weight | 527.8 |
Formula | C23H22Cl3FN4O3 |
Cas No. | 1429757-68-5 |
Smiles | Cl.COc1cc2ncnc(Nc3ccc(Cl)c(Cl)c3F)c2cc1OC1CCN(CC1)C(=O)C=C |
Relative Density. | no data available |
Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 22.5 mg/mL (42.63 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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