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Poziotinib hydrochloride

🥰Excellent
Catalog No. T8758Cas No. 1429757-68-5
Alias NOV120101 hydrochloride, HM 781-36B hydrochloride

Poziotinib hydrochloride irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. It is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity.

Poziotinib hydrochloride

Poziotinib hydrochloride

🥰Excellent
Purity: 99.69%
Catalog No. T8758Alias NOV120101 hydrochloride, HM 781-36B hydrochlorideCas No. 1429757-68-5
Poziotinib hydrochloride irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. It is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity.
Pack SizePriceAvailabilityQuantity
5 mg$50In Stock
10 mg$75In Stock
25 mg$128In Stock
50 mg$192In Stock
100 mg$287In Stock
200 mg$431In Stock
500 mg$713In Stock
1 mL x 10 mM (in DMSO)$81In Stock
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Purity:99.69%
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Product Introduction

Bioactivity
Description
Poziotinib hydrochloride irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. It is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity.
AliasNOV120101 hydrochloride, HM 781-36B hydrochloride
Chemical Properties
Molecular Weight527.8
FormulaC23H22Cl3FN4O3
Cas No.1429757-68-5
SmilesCl.COc1cc2ncnc(Nc3ccc(Cl)c(Cl)c3F)c2cc1OC1CCN(CC1)C(=O)C=C
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 22.5 mg/mL (42.63 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8947 mL9.4733 mL18.9466 mL94.7329 mL
5 mM0.3789 mL1.8947 mL3.7893 mL18.9466 mL
10 mM0.1895 mL0.9473 mL1.8947 mL9.4733 mL
20 mM0.0947 mL0.4737 mL0.9473 mL4.7366 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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