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Golotimod hydrochloride
😃Good
Catalog No. T11449Cas No. 1029401-59-9
Alias SCV07 hydrochloride, SCV 07 hydrochloride, Golotimod hydrochloride (229305-39-9 free base), Gamma-D-glutamyl-L-tryptophan hydrochloride
Golotimod hydrochloride (SCV 07 hydrochloride) is an immunomodulatory peptide with antibacterial activity that inhibits the homodimerization of STAT3 in the cytoplasm, thereby inhibiting STAT3 signaling. It can be used for studying immune-sensitive diseases and HCV infections.
Golotimod hydrochloride
😃Good
Purity: 99.86%
Catalog No. T11449Alias SCV07 hydrochloride, SCV 07 hydrochloride, Golotimod hydrochloride (229305-39-9 free base), Gamma-D-glutamyl-L-tryptophan hydrochlorideCas No. 1029401-59-9
Golotimod hydrochloride (SCV 07 hydrochloride) is an immunomodulatory peptide with antibacterial activity that inhibits the homodimerization of STAT3 in the cytoplasm, thereby inhibiting STAT3 signaling. It can be used for studying immune-sensitive diseases and HCV infections.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $98 | In Stock | |
| 10 mg | $159 | In Stock | |
| 50 mg | $398 | Backorder | |
| 100 mg | $534 | Backorder | |
| 200 mg | Inquiry | Backorder | |
| 500 mg | Inquiry | Backorder |
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Purity:99.86%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Golotimod hydrochloride (SCV 07 hydrochloride) is an immunomodulatory peptide with antibacterial activity that inhibits the homodimerization of STAT3 in the cytoplasm, thereby inhibiting STAT3 signaling. It can be used for studying immune-sensitive diseases and HCV infections. |
| In vitro | Golotimod hydrochloride can stimulate T helper cells to shift to TH1-like immune response. Golotimod hydrochloride can stimulate macrophage function decreased by TB infection and isoniazid treatment, and improve phagocytosis activity of peritoneal macrophages. It can be used as a prospective immunomodulator for the complex treatment of tuberculosis (TB). [1] |
| In vivo | Oral administration of Golotimod hydrochloride at a dose of 5μg/kg after fasting overnight significantly reduced infectional recurrent lesions in recurrent genital HSV-2 guinea pigs. [2] Golotimod hydrochloride is able to alter the duration and severity of oral mucositis and depends on time and dose. |
| Alias | SCV07 hydrochloride, SCV 07 hydrochloride, Golotimod hydrochloride (229305-39-9 free base), Gamma-D-glutamyl-L-tryptophan hydrochloride |
| Molecular Weight | 369.8 |
| Formula | C16H20ClN3O5 |
| Cas No. | 1029401-59-9 |
| Smiles | C([C@@H](NC(CC[C@H](C(O)=O)N)=O)C(O)=O)C=1C=2C(NC1)=CC=CC2.Cl |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 120 mg/mL (324.5 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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