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PD-161570
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Purity:99.23%
PD-161570
Catalog No. T23127Cas No. 192705-80-9
PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. It also inhibits the PDGFR, EGFR, and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $98 | In Stock | |
| 2 mg | $138 | In Stock | |
| 5 mg | $222 | In Stock | |
| 10 mg | $328 | In Stock | |
| 25 mg | $553 | In Stock | |
| 50 mg | $789 | In Stock | |
| 100 mg | $1,070 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $258 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. It also inhibits the PDGFR, EGFR, and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively. |
| Targets&IC50 | FGFR1:39.9 nM (IC50), FGFR1 autophosphorylation:622 nM, FGFR1:42 nM (Ki) |
| Alias | PD 161570 |
| Molecular Weight | 532.51 |
| Formula | C26H35Cl2N7O |
| Cas No. | 192705-80-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (56.34 mM), Sonication is recommended. Ethanol: < 53.25 mg/mL | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Keywords
InhibitorFibroblast growth factor receptorHER1kinasesautophosphorylationPDGFRFGFRSrcinhibitTGF-β ReceptorATP-competitiveEpidermal growth factor receptortyrosinePlatelet-derived growth factor receptordiseaseEGFRanti-cancerangiogenesisErbB-1PD-161570PD161570FGFR1Transforming growth factor beta receptorscardiovascularanti-proliferation
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