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(Rac)-AMXT-1501 4HCl is a polyamine transport inhibitor that inhibits polyamine transport and acts synergistically with cisplatin in HNSCC. (Rac)-AMXT-1501 4HCl has potential antimicrobial activity and inhibits neuroblastoma cell proliferation and pneumococcal pod biosynthesis by targeting ornithine decarboxylase and polyamine transport.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $183 | In Stock | |
2 mg | $269 | In Stock | |
5 mg | $456 | In Stock | |
10 mg | $697 | In Stock | |
25 mg | $1,530 | In Stock | |
50 mg | $2,360 | In Stock |
Description | (Rac)-AMXT-1501 4HCl is a polyamine transport inhibitor that inhibits polyamine transport and acts synergistically with cisplatin in HNSCC. (Rac)-AMXT-1501 4HCl has potential antimicrobial activity and inhibits neuroblastoma cell proliferation and pneumococcal pod biosynthesis by targeting ornithine decarboxylase and polyamine transport. |
In vitro | In BE(2)-C, SMS-KCNR, and SH-SY5Y cells, AMXT-1501 tetrahydrochloride (0.39 µM, 1 µM, 3.1 µM, 10 µM, 31 µM, 50 µM; 48 hours) exhibited cytotoxicity against this panel of NB cell lines[2]. |
In vivo | In C57BL/6 (WT) and experimental autoimmune encephalomyelitis (EAE) model-bearing ODC knockout strain (ODC cKO) mice, AMXT-1501 tetrahydrochloride (3 mg/kg; subcutaneous injection; once daily; 28 days) initially displayed a delayed disease onset but eventually proceeded with pathological development and reached the endpoint[3]. |
Molecular Weight | 714.77 |
Formula | C32H72Cl4N6O2 |
Cas No. | 2771343-93-0 |
Smiles | O=C(CCCCCCCCCCCCCCC)NCCCCC(C(NCCCNCCCCNCCCN)=O)N.Cl.Cl.Cl.Cl |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | H2O: 60 mg/mL (83.94 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O
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