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PROTAC CDK4/6 degrader 1

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Catalog No. T88727Cas No. 3025082-14-5

PROTAC CDK4/6 degrader 1 (Compound 7f) is a dual degrader of CDK4 and CDK6, with DC50 values of 10.5 nM and 2.5 nM, respectively. This compound effectively inhibits proliferation in Jurkat cells (IC50 of 0.18 μM), induces cell cycle arrest during the G1 phase, and triggers cell apoptosis (apoptosis). It features a pink ligand for target protein YY173, a black linker, and a blue ligand for E3 ligase.

PROTAC CDK4/6 degrader 1

PROTAC CDK4/6 degrader 1

😃Good
Catalog No. T88727Cas No. 3025082-14-5
PROTAC CDK4/6 degrader 1 (Compound 7f) is a dual degrader of CDK4 and CDK6, with DC50 values of 10.5 nM and 2.5 nM, respectively. This compound effectively inhibits proliferation in Jurkat cells (IC50 of 0.18 μM), induces cell cycle arrest during the G1 phase, and triggers cell apoptosis (apoptosis). It features a pink ligand for target protein YY173, a black linker, and a blue ligand for E3 ligase.
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Product Introduction

Bioactivity
Description
PROTAC CDK4/6 degrader 1 (Compound 7f) is a dual degrader of CDK4 and CDK6, with DC50 values of 10.5 nM and 2.5 nM, respectively. This compound effectively inhibits proliferation in Jurkat cells (IC50 of 0.18 μM), induces cell cycle arrest during the G1 phase, and triggers cell apoptosis (apoptosis). It features a pink ligand for target protein YY173, a black linker, and a blue ligand for E3 ligase.
Targets&IC50
CDK4:10.5 nM (DC 50 ), CDK6:2.5 nM (DC 50 )
Chemical Properties
Molecular Weight789.88
FormulaC41H47N11O6
Cas No.3025082-14-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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