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Rilmenidine hemifumarate
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Rilmenidine hemifumarate
Catalog No. T21911Cas No. 207572-68-7
Rilmenidine hemifumarate (S-3341 hemifumarate) is a novel, orally active and selective I1 imidazoline receptor and α2-adrenoceptor agonist that induces autophagy, regulates the proliferation of leukaemia cells, stimulates the pro-apoptotic protein Bax, and induces autophagy in human leukaemia K5 cells. induces disruption of the mitochondrial pathway and apoptosis in human leukaemia K562 cells.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $72 | In Stock | |
| 10 mg | $98 | In Stock | |
| 25 mg | $168 | In Stock | |
| 50 mg | $247 | In Stock | |
| 100 mg | $365 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Rilmenidine hemifumarate (S-3341 hemifumarate) is a novel, orally active and selective I1 imidazoline receptor and α2-adrenoceptor agonist that induces autophagy, regulates the proliferation of leukaemia cells, stimulates the pro-apoptotic protein Bax, and induces autophagy in human leukaemia K5 cells. induces disruption of the mitochondrial pathway and apoptosis in human leukaemia K562 cells. |
| In vitro | Rilmenidine provides antihypertensive efficacy comparable with that of diuretics, beta-blockers, calcium channel blockers, and angiotensin-converting enzyme (ACE) inhibitors. Rilmenidine (25-100 μM; 24 hours) inhibits K562 cell proliferation[3]. |
| In vivo | In Rilmenidine-treated N171-82Q mice (i.p.; 4-times a week), significant improvement in forelimb grip strength and all limbs grip strength is observed from 12 to 22 weeks of age. Rilmenidine also decreases levels of mutant huntingtin[2]. |
| Alias | Rilmenidine (hemifumarate), S-3341 hemifumarate |
| Molecular Weight | 238.28 |
| Formula | C12H18O3 |
| Cas No. | 207572-68-7 |
| Storage | store at low temperature,store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 30 mg/mL (125.90 mM) DMSO: 5 mg/mL (125.90 mM) | |||||||||||||||||||||||||||||||||||
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