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Rilmenidine hemifumarate
😃Good
Catalog No. T21911Cas No. 207572-68-7
Alias S-3341 hemifumarate, Rilmenidine (hemifumarate)
Rilmenidine hemifumarate (S-3341 hemifumarate) is a novel, orally active and selective I1 imidazoline receptor and α2-adrenoceptor agonist that induces autophagy, regulates the proliferation of leukaemia cells, stimulates the pro-apoptotic protein Bax, and induces autophagy in human leukaemia K5 cells. induces disruption of the mitochondrial pathway and apoptosis in human leukaemia K562 cells.
Rilmenidine hemifumarate
😃Good
Purity: 98.14%
Catalog No. T21911Alias S-3341 hemifumarate, Rilmenidine (hemifumarate)Cas No. 207572-68-7
Rilmenidine hemifumarate (S-3341 hemifumarate) is a novel, orally active and selective I1 imidazoline receptor and α2-adrenoceptor agonist that induces autophagy, regulates the proliferation of leukaemia cells, stimulates the pro-apoptotic protein Bax, and induces autophagy in human leukaemia K5 cells. induces disruption of the mitochondrial pathway and apoptosis in human leukaemia K562 cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | 68 € | 1-2 weeks | |
| 10 mg | 93 € | 1-2 weeks | |
| 25 mg | 159 € | 1-2 weeks | |
| 50 mg | 234 € | 1-2 weeks | |
| 100 mg | 346 € | 1-2 weeks |
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Purity:98.14%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Rilmenidine hemifumarate (S-3341 hemifumarate) is a novel, orally active and selective I1 imidazoline receptor and α2-adrenoceptor agonist that induces autophagy, regulates the proliferation of leukaemia cells, stimulates the pro-apoptotic protein Bax, and induces autophagy in human leukaemia K5 cells. induces disruption of the mitochondrial pathway and apoptosis in human leukaemia K562 cells. |
| In vitro | Rilmenidine offers antihypertensive efficacy comparable to diuretics, beta-blockers, calcium channel blockers, and angiotensin-converting enzyme (ACE) inhibitors. Rilmenidine (25-100 μM; 24 hours) also inhibits K562 cell proliferation[3]. |
| In vivo | In Rilmenidine-treated N171-82Q mice (i.p.; 4-times a week), significant improvement in forelimb grip strength and all limbs grip strength is observed from 12 to 22 weeks of age. Rilmenidine also decreases levels of mutant huntingtin[2]. |
| Alias | S-3341 hemifumarate, Rilmenidine (hemifumarate) |
| Molecular Weight | 238.28 |
| Formula | C10H16N2O.1/2C4H4O4 |
| Cas No. | 207572-68-7 |
| Smiles | C1CC1C(C2CC2)NC3=NCCO3.C1CC1C(C2CC2)NC3=NCCO3.C(=CC(=O)O)C(=O)O |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 30 mg/mL (125.90 mM) DMSO: 5 mg/mL (125.90 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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