Powder: -20°C for 3 years | In solvent: -80°C for 1 year
The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 μM) and JNK3 (Ki = 4 μM). CAY10561 inhibits proliferation of COLO 205 cells with an IC50 value of 0.54 μM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 μg | 35 days | $ 65.00 | |
1 mg | 35 days | $ 120.00 | |
5 mg | 35 days | $ 488.00 | |
10 mg | 35 days | $ 853.00 |
Description | The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 μM) and JNK3 (Ki = 4 μM). CAY10561 inhibits proliferation of COLO 205 cells with an IC50 value of 0.54 μM. |
Molecular Weight | 459.3 |
Formula | C22H17Cl2FN4O2 |
CAS No. | 933786-58-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 5 mg/mL
Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/mL
DMF: 2.5 mg/mL
DMSO: 1.5 mg/mL
You can also refer to dose conversion for different animals. More
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CAY10561 933786-58-4 CAY 10561 CAY-10561 inhibitor inhibit