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(S)-Coriolic acid

(S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent generated by the reaction of linoleic acid with plant and mammalian lipoxygenases. It is involved in cell proliferation and differentiation in various biological systems and inhibits the adhesion of tumor cells to the vascular endothelium, while down-regulating IRGpIIb/IIIa receptor expression at around 1 μM. Additionally, (S)-Coriolic acid is a metabolite of 15-lipoxygenase (15-LOX) and often acts as an endogenous ligand to activate PPARγ. It induces mitochondrial dysfunction and airway epithelial damage.

Catalog No. T37974Cas No. 29623-28-7

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Concentration:0.1 mg/mL

Purity:97.67%

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COA HNMR HPLC

(S)-Coriolic acid

Catalog No. T37974Cas No. 29623-28-7

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Pack Size	Price	Availability
100 ug (337.33 μM* 1 mL in Ethanol)	$389	In Stock
250 ug (337.33 μM * 2.5 mL in Ethanol)	$780	6-8 weeks
500 ug (337.33 μM * 5 mL in Ethanol)	$1,450	6-8 weeks

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Product Introduction

Bioactivity

Description	(S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent generated by the reaction of linoleic acid with plant and mammalian lipoxygenases. It is involved in cell proliferation and differentiation in various biological systems and inhibits the adhesion of tumor cells to the vascular endothelium, while down-regulating IRGpIIb/IIIa receptor expression at around 1 μM. Additionally, (S)-Coriolic acid is a metabolite of 15-lipoxygenase (15-LOX) and often acts as an endogenous ligand to activate PPARγ. It induces mitochondrial dysfunction and airway epithelial damage.
In vitro	(S)-Coriolic acid (30 nM; 6 h; E-FABP-/- keratinocytes) induces K1 expression through NF-κB activation. (S)-Coriolic acid also increases the phosphorylation of Ikkinase-bat tyrosine 199, which promotes IκBα phosphorylation and subsequent NF-kB activation. (S)-Coriolic acid increases the phosphorylation of IκBαat serine 32, which induces IκB degradation and thereby activates NF-κB.[3]
In vivo	(S)-Coriolic acid (0-0.6 mg; intranasal; once daily for 3 consecutive days; mouse) induces significant airway dysfunction, neutrophilia, mitochondrial dysfunction, and epithelial injury.[2]
Alias	13(S)-HODE

Chemical Properties

Molecular Weight	296.44
Formula	C₁₈H₃₂O₃
Cas No.	29623-28-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

Ethanol: >50 mg/mL (per Rao Maddipati)

DMSO: 55 mg/mL (185.54 mM)

PBS (pH 7.2): 1 mg/mL

DMF: >50 mg/mL (per Rao Maddipati)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3734 mL	16.8668 mL	33.7336 mL	168.6682 mL
5 mM	0.6747 mL	3.3734 mL	6.7467 mL	33.7336 mL
10 mM	0.3373 mL	1.6867 mL	3.3734 mL	16.8668 mL
20 mM	0.1687 mL	0.8433 mL	1.6867 mL	8.4334 mL
50 mM	0.0675 mL	0.3373 mL	0.6747 mL	3.3734 mL
100 mM	0.0337 mL	0.1687 mL	0.3373 mL	1.6867 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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