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(S)-Coriolic acid
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Catalog No. T37974Cas No. 29623-28-7
Alias 13(S)-HODE
(S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent generated by the reaction of linoleic acid with plant and mammalian lipoxygenases. It is involved in cell proliferation and differentiation in various biological systems and inhibits the adhesion of tumor cells to the vascular endothelium, while down-regulating IRGpIIb/IIIa receptor expression at around 1 μM. Additionally, (S)-Coriolic acid is a metabolite of 15-lipoxygenase (15-LOX) and often acts as an endogenous ligand to activate PPARγ. It induces mitochondrial dysfunction and airway epithelial damage.
(S)-Coriolic acid
😃Good
Purity: 97.67%
Catalog No. T37974Alias 13(S)-HODECas No. 29623-28-7
(S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent generated by the reaction of linoleic acid with plant and mammalian lipoxygenases. It is involved in cell proliferation and differentiation in various biological systems and inhibits the adhesion of tumor cells to the vascular endothelium, while down-regulating IRGpIIb/IIIa receptor expression at around 1 μM. Additionally, (S)-Coriolic acid is a metabolite of 15-lipoxygenase (15-LOX) and often acts as an endogenous ligand to activate PPARγ. It induces mitochondrial dysfunction and airway epithelial damage.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 ug (337.33 μM* 1 mL in Ethanol) | $389 | In Stock | |
| 250 ug (337.33 μM * 2.5 mL in Ethanol) | $780 | 6-8 weeks | |
| 500 ug (337.33 μM * 5 mL in Ethanol) | $1,450 | 6-8 weeks |
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CitedSelect Batch
Concentration:0.1 mg/mL
Purity:97.67%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | (S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent generated by the reaction of linoleic acid with plant and mammalian lipoxygenases. It is involved in cell proliferation and differentiation in various biological systems and inhibits the adhesion of tumor cells to the vascular endothelium, while down-regulating IRGpIIb/IIIa receptor expression at around 1 μM. Additionally, (S)-Coriolic acid is a metabolite of 15-lipoxygenase (15-LOX) and often acts as an endogenous ligand to activate PPARγ. It induces mitochondrial dysfunction and airway epithelial damage. |
| In vitro | (S)-Coriolic acid (30 nM; 6 h; E-FABP-/- keratinocytes) induces K1 expression through NF-κB activation. (S)-Coriolic acid also increases the phosphorylation of Ikkinase-bat tyrosine 199, which promotes IκBα phosphorylation and subsequent NF-kB activation. (S)-Coriolic acid increases the phosphorylation of IκBαat serine 32, which induces IκB degradation and thereby activates NF-κB.[3] |
| In vivo | (S)-Coriolic acid (0-0.6 mg; intranasal; once daily for 3 consecutive days; mouse) induces significant airway dysfunction, neutrophilia, mitochondrial dysfunction, and epithelial injury.[2] |
| Alias | 13(S)-HODE |
| Molecular Weight | 296.44 |
| Formula | C18H32O3 |
| Cas No. | 29623-28-7 |
| Smiles | C(=C/C=C\CCCCCCCC(O)=O)\[C@H](CCCCC)O |
| Relative Density. | 0.970 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: >50 mg/mL (per Rao Maddipati) DMSO: 55 mg/mL (185.54 mM)  PBS (pH 7.2): 1 mg/mL DMF: >50 mg/mL (per Rao Maddipati) | |||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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