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Malotilate
🥰Excellent
Catalog No. T6576Cas No. 59937-28-9
Alias NKK 105, Malotilatum, Kantec
Malotilate (Kantec) is a medicine used for the therapy of liver cirrhosis.
Malotilate
🥰Excellent
Purity: 99.98%
Catalog No. T6576Alias NKK 105, Malotilatum, KantecCas No. 59937-28-9
Malotilate (Kantec) is a medicine used for the therapy of liver cirrhosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $45 | In Stock | |
| 10 mg | $72 | In Stock | |
| 25 mg | $91 | In Stock | |
| 50 mg | $122 | In Stock | |
| 100 mg | $198 | In Stock | |
| 200 mg | $258 | In Stock | |
| 500 mg | $433 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $58 | In Stock |
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Purity:99.98%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Malotilate (Kantec) is a medicine used for the therapy of liver cirrhosis. |
| Targets&IC50 | 5-LOX:4.7 μM (IC50) |
| In vitro | Malotilate caused a significant decrease in the invasion of C-SST-2 cells in RLE monolayers.Malotilate inhibited the increased permeability of RLE monolayers by serum starvation. By enhancing the intercellular contact of endothelial cells, Malotilate prevented the invasion of tumor cells into the vascular endothelium and inhibited tumor metastasis. In multilayer cultures, Malotilate (0.1-100 μM) concentration-dependently increased collagenase activity but did not affect monolayer cells. In damaged multilayer cultures, Malotilate increased MMP-1 and MMP-3 secretion, also without affecting monolayer cells. |
| In vivo | Malotilate caused a significant decrease in the invasion of C-SST-2 cells in RLE monolayers.Malotilate inhibited the increased permeability of RLE monolayers by serum starvation. By enhancing the intercellular contact of endothelial cells, Malotilate prevented the invasion of tumor cells into the vascular endothelium and inhibited tumor metastasis. In multilayer cultures, Malotilate (0.1-100 μM) concentration-dependently increased collagenase activity but did not affect monolayer cells. In damaged multilayer cultures, Malotilate increased MMP-1 and MMP-3 secretion, also without affecting monolayer cells. |
| Alias | NKK 105, Malotilatum, Kantec |
| Molecular Weight | 288.38 |
| Formula | C12H16O4S2 |
| Cas No. | 59937-28-9 |
| Smiles | C(C(OC(C)C)=O)(C(OC(C)C)=O)=C1SC=CS1 |
| Relative Density. | 1.3727 g/cm3 (Estimated) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 58 mg/mL (201.12 mM) DMSO: 55 mg/mL (190.72 mM)  H2O: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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