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M-110

M-110
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Purity:98.30%
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M-110

Catalog No. T15830Cas No. 1395048-49-3
M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases, showing a preference for PIM-3 (IC50=47 nM), and inhibits PIM-1 and PIM-2 with similar IC50s of 2.5 μM. M-110 also inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 μM.
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Pack SizePriceAvailabilityQuantity
5 mg$58In Stock
10 mg$93In Stock
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50 mgInquiryIn Stock
1 mL x 10 mM (in DMSO)$58In Stock
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Product Introduction

Bioactivity
Description
M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases, showing a preference for PIM-3 (IC50=47 nM), and inhibits PIM-1 and PIM-2 with similar IC50s of 2.5 μM. M-110 also inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 μM.
In vitro
M-110 has no activity on normal human peripheral blood mononuclear cells up to 40 μM. M-110 inhibits the expression of active STAT3 through inhibition of PIM-3. M-110 also inhibits the proliferation of 22Rv1, PC3, and SW480 cells, with IC50 values of 0.6 to 0.8 μM. M-110 (0.01-10 μM; 72 hours) inhibiting the growth of DU-145 cells (IC50: 0.9 μM). M-110 (10 μM; 18 hours) inhibits STAT3 Tyr705 phosphorylation[1].
Chemical Properties
Molecular Weight445.94
FormulaC22H28ClN5O3
Cas No.1395048-49-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (112.12 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2425 mL11.2123 mL22.4245 mL112.1227 mL
5 mM0.4485 mL2.2425 mL4.4849 mL22.4245 mL
10 mM0.2242 mL1.1212 mL2.2425 mL11.2123 mL
20 mM0.1121 mL0.5606 mL1.1212 mL5.6061 mL
50 mM0.0448 mL0.2242 mL0.4485 mL2.2425 mL
100 mM0.0224 mL0.1121 mL0.2242 mL1.1212 mL

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