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Pim-1/2 kinase inhibitor 1

Pim-1/2 kinase inhibitor 1
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Purity:99.89%
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Pim-1/2 kinase inhibitor 1

Catalog No. T9229Cas No. 6320-51-0
Pim-1/2 Kinase Inhibitor 1, an orally active inhibitor, impedes the action of Pim kinases by preventing their ability to phosphorylate peptides. It particularly inhibits the phosphorylation of 4E-BP1 and p27 Kip1 by Pim protein kinases. This compound is valuable in cancer research, with a notable application in studying prostate cancer [1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$34In Stock
5 mg$77In Stock
10 mg$127In Stock
25 mg$255In Stock
50 mg$397In Stock
100 mg$596In Stock
500 mg$1,250In Stock
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Product Introduction

Bioactivity
Description
Pim-1/2 Kinase Inhibitor 1, an orally active inhibitor, impedes the action of Pim kinases by preventing their ability to phosphorylate peptides. It particularly inhibits the phosphorylation of 4E-BP1 and p27 Kip1 by Pim protein kinases. This compound is valuable in cancer research, with a notable application in studying prostate cancer [1].
In vitro
Pim-1/2 kinase inhibitor 1 (compound D14) exhibits cytotoxicity to PC3 cells, with an IC of 11 μM after 48 hours of incubation at varying concentrations [1].
Chemical Properties
Molecular Weight235.26
FormulaC11H9NO3S
Cas No.6320-51-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (212.53 mM), Sonication and heating to 60℃ are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.2506 mL21.2531 mL42.5062 mL212.5308 mL
5 mM0.8501 mL4.2506 mL8.5012 mL42.5062 mL
10 mM0.4251 mL2.1253 mL4.2506 mL21.2531 mL
20 mM0.2125 mL1.0627 mL2.1253 mL10.6265 mL
50 mM0.0850 mL0.4251 mL0.8501 mL4.2506 mL
100 mM0.0425 mL0.2125 mL0.4251 mL2.1253 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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