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XL413 HCl
Catalog No. T71339Cas No. 1169562-71-3
Alias XL413 hydrochloride, BMS-863233 HCl
XL413 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.XL413 HCl inhibited CK2 and PIM1 with IC50 values of 215 and 42 nM, respectively.XL413 HCl showed an EC50 value of 118 against pMCM.
XL413 HCl
Catalog No. T71339Alias XL413 hydrochloride, BMS-863233 HClCas No. 1169562-71-3
XL413 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.XL413 HCl inhibited CK2 and PIM1 with IC50 values of 215 and 42 nM, respectively.XL413 HCl showed an EC50 value of 118 against pMCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $57 | In Stock | |
| 5 mg | $122 | In Stock | |
| 10 mg | $169 | In Stock | |
| 25 mg | $296 | In Stock | |
| 50 mg | $497 | In Stock | |
| 100 mg | $723 | In Stock | |
| 500 mg | $1,520 | In Stock |
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Purity:99.67%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | XL413 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.XL413 HCl inhibited CK2 and PIM1 with IC50 values of 215 and 42 nM, respectively.XL413 HCl showed an EC50 value of 118 against pMCM. |
| Targets&IC50 | CK2:215 nM, Pim1:42 nM, pMCM:118 nM(EC50), CDC7:3.4 nM |
| In vitro | XL413 HCl shows cytotoxic effects on tumors, with IC50 of 22.9 µM in HCC1954 cells and 1.1 µM in Colo-205 cells.[2]
BMS-863233 HCl is an effective DDK inhibitor in vitro, with an IC50 of 22.7 nM.[2] XL413 HCl is defective in inhibiting DDK-dependent Mcm2 phosphorylation in HCC1954 cells but is effective in Colo-205 cells.[2] |
| In vivo | XL413 HCl (10, 30, or 100 mg/kg; p.o.; mice) is well tolerated at all doses, with no significant body weight loss.[1]
XL413 HCl (100 mg/kg; p.o.; mice) show excellent plasma exposures in mice and possesses good PK properties.[1] |
| Alias | XL413 hydrochloride, BMS-863233 HCl |
| Formula | C14H12ClN3O2.xHCl |
| Cas No. | 1169562-71-3 |
Storage & Solubility Information
| Storage | store at low temperature | Shipping with blue ice. |
| Solubility Information | H2O: 9.0 mg/mL, Sonication is recommended. DMSO: 3.1 mg/mL, Sonication and heating are recommended. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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