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TL4-12
🥰Excellent
Catalog No. T26280Cas No. 1620820-12-3
Alias TL412, TL4 12
TL4-12 is a specific MAP4K2/GCK inhibitor that inhibits IKZF1 and BCL-6.TL4-12 inhibits MM cell proliferation and induces apoptosis, and can be used in the study of multiple myeloma (MM).
TL4-12
🥰Excellent
Purity: 98.38%
Catalog No. T26280Alias TL412, TL4 12Cas No. 1620820-12-3
TL4-12 is a specific MAP4K2/GCK inhibitor that inhibits IKZF1 and BCL-6.TL4-12 inhibits MM cell proliferation and induces apoptosis, and can be used in the study of multiple myeloma (MM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 100 € | In Stock | |
| 5 mg | 202 € | In Stock | |
| 10 mg | 305 € | In Stock | |
| 25 mg | 511 € | In Stock | |
| 50 mg | 729 € | In Stock | |
| 100 mg | 997 € | In Stock | |
| 500 mg | 1.976 € | In Stock |
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Purity:98.38%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | TL4-12 is a specific MAP4K2/GCK inhibitor that inhibits IKZF1 and BCL-6.TL4-12 inhibits MM cell proliferation and induces apoptosis, and can be used in the study of multiple myeloma (MM). |
| In vitro | The GCK inhibitor TL4-12 downregulates IKZF1 and BCL-6 in a dose-dependent manner, resulting in proliferation inhibition and induction of apoptosis in multiple myeloma cells[1]. |
| Alias | TL412, TL4 12 |
| Molecular Weight | 500.52 |
| Formula | C25H27F3N6O2 |
| Cas No. | 1620820-12-3 |
| Smiles | O=C(NC=1C=C(C=C(C1)C(F)(F)F)N2CCN(C)CC2)C3=CC=C(C(OC4=NC=NC(=C4)NC)=C3)C |
| Relative Density. | 1.324 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
| Solubility Information | DMSO: 5 mg/mL (2.00 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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