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VEGFR-3-IN-1
🥰Excellent
Catalog No. T72924Cas No. 2756668-73-0
VEGFR-3-IN-1 is a novel, potent, and selective VEGFR3 inhibitor with an IC50 of 110.4 nM. It exhibits antitumor activity, inactivates the VEGFR3 signaling pathway, and inhibits the proliferation and migration of VEGF-C-induced human dermal lymphatic endothelial cells (HDLEC), MDA-MB-231, and MDA-MB-436 cells.
VEGFR-3-IN-1
🥰Excellent
Purity: 99.52%
Catalog No. T72924Cas No. 2756668-73-0
VEGFR-3-IN-1 is a novel, potent, and selective VEGFR3 inhibitor with an IC50 of 110.4 nM. It exhibits antitumor activity, inactivates the VEGFR3 signaling pathway, and inhibits the proliferation and migration of VEGF-C-induced human dermal lymphatic endothelial cells (HDLEC), MDA-MB-231, and MDA-MB-436 cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $48 | In Stock | |
| 5 mg | $113 | In Stock | |
| 10 mg | $189 | In Stock | |
| 25 mg | $378 | In Stock | |
| 50 mg | $619 | In Stock | |
| 100 mg | $993 | In Stock | |
| 500 mg | $1,980 | In Stock |
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Purity:99.52%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | VEGFR-3-IN-1 is a novel, potent, and selective VEGFR3 inhibitor with an IC50 of 110.4 nM. It exhibits antitumor activity, inactivates the VEGFR3 signaling pathway, and inhibits the proliferation and migration of VEGF-C-induced human dermal lymphatic endothelial cells (HDLEC), MDA-MB-231, and MDA-MB-436 cells. |
| Targets&IC50 | VEGFR3:110.4 nM |
| In vitro | VEGFR-3-IN-1 (50, 25 mg/kg; oral; once; nude mice) achieved the most potent tumor volume inhibition in nude mice, with an inhibition rate of 61.9%.The results of VEGFR-3-IN-1 (10 mg/kg; oral) post-treatment showed a maximal concentration (Cmax) of 420 ng/mL, an AUC0-t of 9219 ng-h /mL, AUC0-∞ of 12,304 ng-h/mL, and a half-life (t1/2) of 16 hours. |
| In vivo | VEGFR-3-IN-1 (50, 25 mg/kg; oral; once; nude mice) achieved the most potent tumor volume inhibition in nude mice, with an inhibition rate of 61.9%.The results of VEGFR-3-IN-1 (10 mg/kg; oral) post-treatment showed a maximal concentration (Cmax) of 420 ng/mL, an AUC0-t of 9219 ng-h /mL, AUC0-∞ of 12,304 ng-h/mL, and a half-life (t1/2) of 16 hours. |
| Molecular Weight | 616.1 |
| Formula | C29H29ClF3N7OS |
| Cas No. | 2756668-73-0 |
| Smiles | C(NC1=CC(C(F)(F)F)=C(Cl)C=C1)(=O)N2CCN(C3=C4C(SC(=C4)C5=CC=C(C=C5)N6CCN(C)CC6)=NC=N3)CC2 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
| Solubility Information | DMSO: 1 mg/ml, Sonication is recommended.  |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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